Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

MOB2 - Mob2p

Saccharomyces cerevisiae S288c

Synonyms: CBK1 kinase activator protein MOB2, MPS1 binder 2, Maintenance of ploidy protein MOB2, YFL034C-B, YFL035C, ...

Weiss, E.L. et al., Schneper, L. et al., Luca, F.C. et al., Colman-Lerner, A. et al.

Colman-Lerner, Chin, Brent,

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High impact information on MOB2

We show that Cbk1 kinase and its interacting protein Mob2 regulate this asymmetry by inducing daughter-specific genetic programs [1].
Furthermore, nuclear localization of Mob2p and Ace2p does not occur in mob1-77 or cdc14-1 mutants, which are defective in MEN signaling, even when cell cycle arrest is bypassed [2].
Both Mob2p and Cbk1p localize interdependently to the bud cortex during polarized growth and to the bud neck and daughter cell nucleus during late mitosis [2].
Mob1p contains no known structural motifs; however MOB1 is a member of a conserved gene family and shares sequence similarity with a nonessential yeast gene, MOB2 [3].
The Ras/protein kinase A pathway acts in parallel with the Mob2/Cbk1 pathway to effect cell cycle progression and proper bud site selection [4].

Biological context of MOB2

We have found that mutations in MOB2 or CBK1 confer a slow-growth phenotype in a ras2Delta background [4].
We found that Ace2p is restricted to daughter cell nuclei via a novel mechanism requiring Mob2p, Cbk1p, and a functional nuclear export pathway [2].

References

Yeast Cbk1 and Mob2 activate daughter-specific genetic programs to induce asymmetric cell fates. Colman-Lerner, A., Chin, T.E., Brent, R. Cell (2001) [Pubmed]
The Saccharomyces cerevisiae Mob2p-Cbk1p kinase complex promotes polarized growth and acts with the mitotic exit network to facilitate daughter cell-specific localization of Ace2p transcription factor. Weiss, E.L., Kurischko, C., Zhang, C., Shokat, K., Drubin, D.G., Luca, F.C. J. Cell Biol. (2002) [Pubmed]
MOB1, an essential yeast gene required for completion of mitosis and maintenance of ploidy. Luca, F.C., Winey, M. Mol. Biol. Cell (1998) [Pubmed]
The Ras/protein kinase A pathway acts in parallel with the Mob2/Cbk1 pathway to effect cell cycle progression and proper bud site selection. Schneper, L., Krauss, A., Miyamoto, R., Fang, S., Broach, J.R. Eukaryotic Cell (2004) [Pubmed]

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