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Gene Review:

ATS1 - Ats1p

Saccharomyces cerevisiae

Kirkpatrick, D., Shields, C.M., Fichtner, L.

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High impact information on ATS1

Thus, we identified yeast open reading frames (ORFs) YBL071w-A and YAL020c/ATS1 as KTI11 and KTI13 respectively [1].
The predicted ATS1 protein contains 333 amino acids and has considerable structural homology to the products of both the mammalian mitotic control gene RCC1 and the S. cerevisiae gene SRM1/PRP20 [2].
Deletion of ATS1 confers a modest slow growth phenotype which is slightly enhanced in strains containing both a deletion of ATS1 and a class 2 tub 1 mutation [2].
Saccharomyces cerevisiae Ats1p interacts with Nap1p, a cytoplasmic protein that controls bud morphogenesis [3].
Our results suggest Ats1p might regulate coordination of the microtubule state with the cell cycle through an interaction with Nap1p [3].

Other interactions of ATS1

Nap1p and Ats1p interact in two-hybrid and co-immunoprecipitation assays [3].

Analytical, diagnostic and therapeutic context of ATS1

Both loci, KTI11 and KTI13, are actively transcribed protein-encoding genes as determined by reverse transcriptase-polymerase chain reaction (RT-PCR) and in vivo HA epitope tagging [1].

References

KTI11 and KTI13, Saccharomyces cerevisiae genes controlling sensitivity to G1 arrest induced by Kluyveromyces lactis zymocin. Fichtner, L., Schaffrath, R. Mol. Microbiol. (2002)
Overexpression of yeast homologs of the mammalian checkpoint gene RCC1 suppresses the class of alpha-tubulin mutations that arrest with excess microtubules. Kirkpatrick, D., Solomon, F. Genetics (1994)
Saccharomyces cerevisiae Ats1p interacts with Nap1p, a cytoplasmic protein that controls bud morphogenesis. Shields, C.M., Taylor, R., Nazarenus, T., Cheatle, J., Hou, A., Tapprich, A., Haifley, A., Atkin, A.L. Curr. Genet. (2003)

ATS1 - Ats1p

Saccharomyces cerevisiae

High impact information on ATS1

Other interactions of ATS1

Analytical, diagnostic and therapeutic context of ATS1

References

Editor

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