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TPD3  -  Regulatory subunit A of the heterotrimeric...

Saccharomyces cerevisiae

 
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High impact information on TPD3

 

Biological context of TPD3

  • Therefore, the mitotic checkpoint activity of CDC55 (and TPD3) is independent of regulated phosphorylation of Cdc28p [4].
  • Computer modeling of PP2Ac structure revealed that interfering amino acid substitutions clustered to the active site, and consistently, the PP2Ac-L199P mutant protein was catalytically impaired despite binding Tpd3p [5].
  • We found the following: the level of each subunit remained constant throughout the cell cycle; there is at least 10 times more of one of the regulatory subunits (Rts1p) than the other (Cdc55p); Tpd3p, the structural subunit, is limiting for both catalytic and regulatory subunit binding [6].
 

Other interactions of TPD3

References

  1. A ceramide-activated protein phosphatase mediates ceramide-induced G1 arrest of Saccharomyces cerevisiae. Nickels, J.T., Broach, J.R. Genes Dev. (1996)
  2. Tor proteins and protein phosphatase 2A reciprocally regulate Tap42 in controlling cell growth in yeast. Jiang, Y., Broach, J.R. EMBO J. (1999)
  3. Inactivation of the protein phosphatase 2A regulatory subunit A results in morphological and transcriptional defects in Saccharomyces cerevisiae. van Zyl, W., Huang, W., Sneddon, A.A., Stark, M., Camier, S., Werner, M., Marck, C., Sentenac, A., Broach, J.R. Mol. Cell. Biol. (1992)
  4. Cdc55p, the B-type regulatory subunit of protein phosphatase 2A, has multiple functions in mitosis and is required for the kinetochore/spindle checkpoint in Saccharomyces cerevisiae. Wang, Y., Burke, D.J. Mol. Cell. Biol. (1997)
  5. Functional expression of human PP2Ac in yeast permits the identification of novel C-terminal and dominant-negative mutant forms. Evans, D.R., Myles, T., Hofsteenge, J., Hemmings, B.A. J. Biol. Chem. (1999)
  6. Localization of Saccharomyces cerevisiae protein phosphatase 2A subunits throughout mitotic cell cycle. Gentry, M.S., Hallberg, R.L. Mol. Biol. Cell (2002)
  7. The scaffolding A/Tpd3 subunit and high phosphatase activity are dispensable for Cdc55 function in the Saccharomyces cerevisiae spindle checkpoint and in cytokinesis. Koren, R., Rainis, L., Kleinberger, T. J. Biol. Chem. (2004)
 
 
 
 
 
 
 
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