Gene Review:
RAM1 - protein farnesyltransferase
Saccharomyces cerevisiae S288c
Synonyms:
CAAX farnesyltransferase subunit beta, D2412, DPR1, FTase-beta, FUS8, ...
- RAM2, an essential gene of yeast, and RAM1 encode the two polypeptide components of the farnesyltransferase that prenylates a-factor and Ras proteins. He, B., Chen, P., Chen, S.Y., Vancura, K.L., Michaelis, S., Powers, S. Proc. Natl. Acad. Sci. U.S.A. (1991)
- Role of SGP2, a suppressor of a gpa1 mutation, in the mating-factor signaling pathway of Saccharomyces cerevisiae. Nakayama, N., Arai, K., Matsumoto, K. Mol. Cell. Biol. (1988)
- RAM, a gene of yeast required for a functional modification of RAS proteins and for production of mating pheromone a-factor. Powers, S., Michaelis, S., Broek, D., Santa Anna, S., Field, J., Herskowitz, I., Wigler, M. Cell (1986)
- Dependence of Ypt1 and Sec4 membrane attachment on Bet2. Rossi, G., Yu, J.A., Newman, A.P., Ferro-Novick, S. Nature (1991)
- Enzymatic coupling of cholesterol intermediates to a mating pheromone precursor and to the ras protein. Schafer, W.R., Trueblood, C.E., Yang, C.C., Mayer, M.P., Rosenberg, S., Poulter, C.D., Kim, S.H., Rine, J. Science (1990)
- Cell fusion during yeast mating requires high levels of a-factor mating pheromone. Brizzio, V., Gammie, A.E., Nijbroek, G., Michaelis, S., Rose, M.D. J. Cell Biol. (1996)
- Farnesylation and proteolysis are sequential, but distinct steps in the CaaX box modification pathway. Farh, L., Mitchell, D.A., Deschenes, R.J. Arch. Biochem. Biophys. (1995)
- Protein farnesyltransferase: production in Escherichia coli and immunoaffinity purification of the heterodimer from Saccharomyces cerevisiae. Mayer, M.P., Prestwich, G.D., Dolence, J.M., Bond, P.D., Wu, H.Y., Poulter, C.D. Gene (1993)
- A novel yeast mutant defective in the processing of ras proteins: assessment of the effect of the mutation on processing steps. Fujiyama, A., Matsumoto, K., Tamanoi, F. EMBO J. (1987)
- Farnesyl cysteine C-terminal methyltransferase activity is dependent upon the STE14 gene product in Saccharomyces cerevisiae. Hrycyna, C.A., Clarke, S. Mol. Cell. Biol. (1990)
- Amino acid substitutions that convert the protein substrate specificity of farnesyltransferase to that of geranylgeranyltransferase type I. Del Villar, K., Mitsuzawa, H., Yang, W., Sattler, I., Tamanoi, F. J. Biol. Chem. (1997)
- Mutants of Saccharomyces cerevisiae defective in the farnesylation of Ras proteins. Goodman, L.E., Judd, S.R., Farnsworth, C.C., Powers, S., Gelb, M.H., Glomset, J.A., Tamanoi, F. Proc. Natl. Acad. Sci. U.S.A. (1990)
- Protein geranylgeranyltransferase of Saccharomyces cerevisiae is specific for Cys-Xaa-Xaa-Leu motif proteins and requires the CDC43 gene product but not the DPR1 gene product. Finegold, A.A., Johnson, D.I., Farnsworth, C.C., Gelb, M.H., Judd, S.R., Glomset, J.A., Tamanoi, F. Proc. Natl. Acad. Sci. U.S.A. (1991)
- Site-directed mutations altering the CAAX box of Ste18, the yeast pheromone-response pathway G gamma subunit. Whiteway, M.S., Thomas, D.Y. Genetics (1994)
- Mutant farnesyltransferase beta subunit of Saccharomyces cerevisiae that can substitute for geranylgeranyltransferase type I beta subunit. Mitsuzawa, H., Esson, K., Tamanoi, F. Proc. Natl. Acad. Sci. U.S.A. (1995)
- Efficient prenylation by a plant geranylgeranyltransferase-I requires a functional CaaL box motif and a proximal polybasic domain. Caldelari, D., Sternberg, H., Rodríguez-Concepción, M., Gruissem, W., Yalovsky, S. Plant Physiol. (2001)