Gene Review:
STE5 - Ste5p
Saccharomyces cerevisiae S288c
Synonyms:
HMD3, NUL3, Protein STE5, YD8557.12, YDR103W
- Mapping of a yeast G protein betagamma signaling interaction. Dowell, S.J., Bishop, A.L., Dyos, S.L., Brown, A.J., Whiteway, M.S. Genetics (1998)
- Constitutive mutants in the yeast pheromone response: ordered function of the gene products. Blinder, D., Bouvier, S., Jenness, D.D. Cell (1989)
- Ste5 RING-H2 domain: role in Ste4-promoted oligomerization for yeast pheromone signaling. Inouye, C., Dhillon, N., Thorner, J. Science (1997)
- Association of the yeast pheromone response G protein beta gamma subunits with the MAP kinase scaffold Ste5p. Whiteway, M.S., Wu, C., Leeuw, T., Clark, K., Fourest-Lieuvin, A., Thomas, D.Y., Leberer, E. Science (1995)
- Function of the MAPK scaffold protein, Ste5, requires a cryptic PH domain. Garrenton, L.S., Young, S.L., Thorner, J. Genes Dev. (2006)
- Mutational activation of the STE5 gene product bypasses the requirement for G protein beta and gamma subunits in the yeast pheromone response pathway. Hasson, M.S., Blinder, D., Thorner, J., Jenness, D.D. Mol. Cell. Biol. (1994)
- Function of the ste signal transduction pathway for mating pheromones sustains MAT alpha 1 transcription in Saccharomyces cerevisiae. Mukai, Y., Harashima, S., Oshima, Y. Mol. Cell. Biol. (1993)
- Mutational analysis suggests that activation of the yeast pheromone response mitogen-activated protein kinase pathway involves conformational changes in the Ste5 scaffold protein. Sette, C., Inouye, C.J., Stroschein, S.L., Iaquinta, P.J., Thorner, J. Mol. Biol. Cell (2000)
- Cloning of Saccharomyces cerevisiae STE5 as a suppressor of a Ste20 protein kinase mutant: structural and functional similarity of Ste5 to Far1. Leberer, E., Dignard, D., Harcus, D., Hougan, L., Whiteway, M., Thomas, D.Y. Mol. Gen. Genet. (1993)
- MAP kinase dynamics in response to pheromones in budding yeast. van Drogen, F., Stucke, V.M., Jorritsma, G., Peter, M. Nat. Cell Biol. (2001)
- Dual role for membrane localization in yeast MAP kinase cascade activation and its contribution to signaling fidelity. Lamson, R.E., Takahashi, S., Winters, M.J., Pryciak, P.M. Curr. Biol. (2006)
- Mutations in the YRB1 gene encoding yeast ran-binding-protein-1 that impair nucleocytoplasmic transport and suppress yeast mating defects. Künzler, M., Trueheart, J., Sette, C., Hurt, E., Thorner, J. Genetics (2001)
- Genetic relationships between the G protein beta gamma complex, Ste5p, Ste20p and Cdc42p: investigation of effector roles in the yeast pheromone response pathway. Akada, R., Kallal, L., Johnson, D.I., Kurjan, J. Genetics (1996)
- Differential input by Ste5 scaffold and Msg5 phosphatase route a MAPK cascade to multiple outcomes. Andersson, J., Simpson, D.M., Qi, M., Wang, Y., Elion, E.A. EMBO J. (2004)
- Saccharomyces cerevisiae STE11 may contribute to the stabilities of a scaffold protein, STE5, in the pheromone signaling pathway. Kim, S.H., Lee, S.K., Choi, K.Y. Mol. Cells (1998)
- Persistent activation by constitutive Ste7 promotes Kss1-mediated invasive growth but fails to support Fus3-dependent mating in yeast. Maleri, S., Ge, Q., Hackett, E.A., Wang, Y., Dohlman, H.G., Errede, B. Mol. Cell. Biol. (2004)
- The MAP kinase Fus3 associates with and phosphorylates the upstream signaling component Ste5. Kranz, J.E., Satterberg, B., Elion, E.A. Genes Dev. (1994)
- Localized feedback phosphorylation of Ste5p scaffold by associated MAPK cascade. Flotho, A., Simpson, D.M., Qi, M., Elion, E.A. J. Biol. Chem. (2004)
- Cdc24 regulates nuclear shuttling and recruitment of the Ste5 scaffold to a heterotrimeric G protein in Saccharomyces cerevisiae. Wang, Y., Chen, W., Simpson, D.M., Elion, E.A. J. Biol. Chem. (2005)
- The Hog1 MAPK prevents cross talk between the HOG and pheromone response MAPK pathways in Saccharomyces cerevisiae. O'Rourke, S.M., Herskowitz, I. Genes Dev. (1998)
- Saccharomyces cerevisiae mutants unresponsive to alpha-factor pheromone: alpha-factor binding and extragenic suppression. Jenness, D.D., Goldman, B.S., Hartwell, L.H. Mol. Cell. Biol. (1987)