The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.
wikigene or wiki gene protein drug chemical gene disease author authorship tracking evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Gene Review: 

SWM1  -  Subunit of the anaphase-promoting complex,...

Saccharomyces cerevisiae

 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text.

Ideally this entry shall become one comprehensive and continuous article. Bulleted lists, for instance, were only used because it is impossible to automatically integrate independent facts into a continuous text.

Much of the current information on this page has been automatically compiled from Pubmed.

This precompiled information serves as a substrate and matrix to embed your contributions, but it is by no means the final word - Homo sapiens can do much better!

WikiGenes is a non-profit and open access community project.

 

 

High impact information on SWM1

  • We have developed a purification strategy that allowed us to purify the budding yeast APC to near homogeneity and identify two novel APC-associated proteins, Swm1p and Mnd2p [1].
  • Deletion of SWM1 specifically affects the expression of mid-late and late sporulation-specific genes [2].
  • We propose that Swm1p, a nuclear protein, would participate in a different signal transduction pathway that is also required for the coordination of the biochemical and morphological events occurring during the last phase of the sporulation program [2].
  • Swm1p subunit of the APC/cyclosome is required for activation of the daughter-specific gene expression program mediated by Ace2p during growth at high temperature in Saccharomyces cerevisiae [3].
  • At the restrictive temperature, swm1 mutants are unable to complete separation, forming chains of cells that remain associated and, with prolonged incubation times, the stability of the cell wall is compromised, resulting in cell lysis [3].
 

Biological context of SWM1

  • SWM1 is expressed at low levels during vegetative growth but its transcription is strongly induced under sporulating conditions, with kinetics similar to those of middle sporulation-specific genes [2].
  • Both Mnd2 and Swm1 were found specifically associated with a highly purified preparation of APC from haploid yeast whole cell extract [4].
 

Other interactions of SWM1

  • Previous studies described meiotic defects for mutations in MND2 and SWM1 [4].
  • In vivo characterization of the nonessential budding yeast anaphase-promoting complex/cyclosome components Swm1p, Mnd2p and Apc9p [5].

References

  1. Doc1 mediates the activity of the anaphase-promoting complex by contributing to substrate recognition. Passmore, L.A., McCormack, E.A., Au, S.W., Paul, A., Willison, K.R., Harper, J.W., Barford, D. EMBO J. (2003)
  2. SWM1, a developmentally regulated gene, is required for spore wall assembly in Saccharomyces cerevisiae. Ufano, S., San-Segundo, P., del Rey, F., Vázquez de Aldana, C.R. Mol. Cell. Biol. (1999)
  3. Swm1p subunit of the APC/cyclosome is required for activation of the daughter-specific gene expression program mediated by Ace2p during growth at high temperature in Saccharomyces cerevisiae. Ufano, S., Pablo, M.E., Calzada, A., del Rey, F., Vázquez de Aldana, C.R. J. Cell. Sci. (2004)
  4. Mnd2 and Swm1 are core subunits of the Saccharomyces cerevisiae anaphase-promoting complex. Hall, M.C., Torres, M.P., Schroeder, G.K., Borchers, C.H. J. Biol. Chem. (2003)
  5. In vivo characterization of the nonessential budding yeast anaphase-promoting complex/cyclosome components Swm1p, Mnd2p and Apc9p. Page, A.M., Aneliunas, V., Lamb, J.R., Hieter, P. Genetics (2005)
 
 
 
 
 
 
 
[search][advanced]

Editor

Links

Table of contents