Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene: INM2 - Inm2p

Saccharomyces cerevisiae

Synonyms: IMP2, IMP 2, IMPase 2, Inositol-1(or 4)-monophosphatase 2, inositol monophosphatase, Inositol monophosphatase, Inositol monophosphatase 2, YDR287W

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Murray, M., Ingavale, S.S., Murray, M., Shaldubina, A., Lopez, F.

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High impact information on YDR287W

However, it does not affect regulation of INM1 (encoding inositol monophosphatase), the expression of which is up-regulated by myo-inositol [1].
The yeast inositol monophosphatase is a lithium- and sodium-sensitive enzyme encoded by a non-essential gene pair [2].
Because the yeast Saccharomyces cerevisiae has been shown to be an excellent model system in which to understand the regulation of inositol metabolism, we characterized inositol monophosphatase in this yeast [3].
Inositol monophosphatase is a key enzyme in the de novo biosynthesis of inositol and in the phosphoinositide second-messenger signalling pathway [3].
The biosynthesis of inositol requires only two enzymes, inositol-1-phosphate synthase (encoded by INO1) and an inositol monophosphatase, but the regulation of inositol biosynthesis is under multiple controls and is exquisitely regulated [4].

Associations of YDR287W with chemical compounds

Expression of yeast INM1 encoding inositol monophosphatase is regulated by inositol, carbon source and growth stage and is decreased by lithium and valproate [5].

References

Epi-inositol regulates expression of the yeast INO1 gene encoding inositol-1-P synthase. Shaldubina, A., Ju, S., Vaden, D.L., Ding, D., Belmaker, R.H., Greenberg, M.L. Mol. Psychiatry (2002)
The yeast inositol monophosphatase is a lithium- and sodium-sensitive enzyme encoded by a non-essential gene pair. Lopez, F., Leube, M., Gil-Mascarell, R., Navarro-Aviñó, J.P., Serrano, R. Mol. Microbiol. (1999)
Regulation of inositol monophosphatase in Saccharomyces cerevisiae. Murray, M., Greenberg, M.L. Mol. Microbiol. (1997)
Restoration of inositol prototrophy in the fission yeast Schizosaccharomyces pombe. Ingavale, S.S., Bachhawat, A.K. Microbiology (Reading, Engl.) (1999)
Expression of yeast INM1 encoding inositol monophosphatase is regulated by inositol, carbon source and growth stage and is decreased by lithium and valproate. Murray, M., Greenberg, M.L. Mol. Microbiol. (2000)

Gene: INM2 - Inm2p

Saccharomyces cerevisiae

High impact information on YDR287W

Associations of YDR287W with chemical compounds

References

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