Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene: BCS1 - Bcs1p

Saccharomyces cerevisiae

Synonyms: D9481.17, Mitochondrial chaperone BCS1, YDR375C

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Nobrega, F.G., Cruciat, C.M., Stan, T., Fölsch, H.

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High impact information on BCS1

We demonstrate here that Bcs1p is directly required for the assembly of the Rieske FeS and Qcr10p proteins into the cytochrome bc(1) complex [1].
Binding of Bcs1p to and release from this assembly intermediate is driven by ATP hydrolysis [1].
Bcs1p, a mitochondrial protein and member of the conserved AAA protein family, is involved in the biogenesis of the cytochrome bc(1) complex [1].
Internal targeting signal of the BCS1 protein: a novel mechanism of import into mitochondria [2].
BCS1, a novel gene required for the expression of functional Rieske iron-sulfur protein in Saccharomyces cerevisiae [3].

Biological context of BCS1

The primary structure of the encoded BCS1 protein bears similarity to a group of proteins that have been implicated in intracellular protein sorting, membrane fusion and regulation of transcription [3].

Anatomical context of BCS1

Both postulated functions are consistent with the localization of BCS1 in mitochondria [3].
We propose that the initial recognition of BCS1 precursor at the surface of the organelle mainly depends on the auxiliary region and does not require the transmembrane domain [4].

Other interactions of BCS1

Mitochondrial protein import: recognition of internal import signals of BCS1 by the TOM complex [4].

References

Bcs1p, an AAA-family member, is a chaperone for the assembly of the cytochrome bc(1) complex. Cruciat, C.M., Hell, K., Fölsch, H., Neupert, W., Stuart, R.A. EMBO J. (1999)
Internal targeting signal of the BCS1 protein: a novel mechanism of import into mitochondria. Fölsch, H., Guiard, B., Neupert, W., Stuart, R.A. EMBO J. (1996)
BCS1, a novel gene required for the expression of functional Rieske iron-sulfur protein in Saccharomyces cerevisiae. Nobrega, F.G., Nobrega, M.P., Tzagoloff, A. EMBO J. (1992)
Mitochondrial protein import: recognition of internal import signals of BCS1 by the TOM complex. Stan, T., Brix, J., Schneider-Mergener, J., Pfanner, N., Neupert, W., Rapaport, D. Mol. Cell. Biol. (2003)