Gene Review:
PIM1 - ATP-dependent Lon protease PIM1
Saccharomyces cerevisiae S288c
Synonyms:
LON, Lon protease homolog, mitochondrial, YBL022C, YBL0440
- PIM1 encodes a mitochondrial ATP-dependent protease that is required for mitochondrial function in the yeast Saccharomyces cerevisiae. Van Dyck, L., Pearce, D.A., Sherman, F. J. Biol. Chem. (1994)
- Pim1, a MAP kinase involved in cell wall integrity in Pichia pastoris. Cosano, I.C., Martín, H., Flández, M., Nombela, C., Molina, M. Mol. Genet. Genomics (2001)
- Requirement for the yeast gene LON in intramitochondrial proteolysis and maintenance of respiration. Suzuki, C.K., Suda, K., Wang, N., Schatz, G. Science (1994)
- The ATP-dependent PIM1 protease is required for the expression of intron-containing genes in mitochondria. van Dyck, L., Neupert, W., Langer, T. Genes Dev. (1998)
- ATP-dependent proteolysis in mitochondria. m-AAA protease and PIM1 protease exert overlapping substrate specificities and cooperate with the mtHsp70 system. Savel'ev, A.S., Novikova, L.A., Kovaleva, I.E., Luzikov, V.N., Neupert, W., Langer, T. J. Biol. Chem. (1998)
- Defects in mRNA 3'-end formation, transcription initiation, and mRNA transport associated with the yeast mutation prp20: possible coupling of mRNA processing and chromatin structure. Forrester, W., Stutz, F., Rosbash, M., Wickens, M. Genes Dev. (1992)
- Hsp78, a Clp homologue within mitochondria, can substitute for chaperone functions of mt-hsp70. Schmitt, M., Neupert, W., Langer, T. EMBO J. (1995)
- Molecular chaperones cooperate with PIM1 protease in the degradation of misfolded proteins in mitochondria. Wagner, I., Arlt, H., van Dyck, L., Langer, T., Neupert, W. EMBO J. (1994)
- Mitochondrial DNA instability mutants of the bifunctional protein Ilv5p have altered organization in mitochondria and are targeted for degradation by Hsp78 and the Pim1p protease. Bateman, J.M., Iacovino, M., Perlman, P.S., Butow, R.A. J. Biol. Chem. (2002)