High impact information on FIG1

• Fig1p and Fig2p are likely to act at the cell surface as Fig1:: beta-gal and Fig2::beta-gal fusion proteins localize to the periphery of mating cells [1].
• We show that deletion of FIG 1, which controls pheromone-induced Ca(2+) influx, yields similar cell fusion defects [2].
• The Plasma Membrane Proteins Prm1 and Fig1 Ascertain Fidelity of Membrane Fusion during Yeast Mating [2].
• Thus, our results suggest that Prm1 and Fig1 have a role in enhancing membrane fusion and maintaining its fidelity [2].
• Rapid cell death required Fig1, a transmembrane protein homologous to PMP-22/EMP/MP20/Claudin proteins, but did not require its Ca2+ influx activity [3].

Biological context of FIG1

• Fig1p and Fig2p are also important for cell fusion and conjugation bridge shape, respectively [1].

Anatomical context of FIG1

• Interestingly a polytopic plasma membrane protein, Fig1p, was required for LACS activity but not required for activation of Mpk1p mitogen-activated protein kinase [4].

Other interactions of FIG1

• Several cochaperone mutants tested had reduced FIG1 induction or HHF1 repression, although to differing extents [5].

References