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Gene Review:

Plcb2 - phospholipase C, beta 2

Rattus norvegicus

Synonyms: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2, PLC-beta-2, Phosphoinositide phospholipase C-beta-2, Phospholipase C-beta-2

LaBelle, E.F. et al., Rössler, P. et al., Park, D. et al., Le Mellay, V. et al., Bieber, E. et al., et al.

Sbarbati, Merigo, Benati, Tizzano, Bernardi, Crescimanno, Osculati,

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Disease relevance of Plcb2

The data also showed that only a PLC beta1 linked to a Pertussis toxin-insensitive G-protein and a PLC beta2 coupled to a Pertussis toxin-sensitive G-protein are involved in the effects of calcitriol and 17beta estradiol on the mobilization of Ca2+ from intracellular Ca2+ stores [1].

High impact information on Plcb2

Inhibition of aldose reductase prevented high glucose-induced DAG formation and phosphorylation of PLC-gamma1 and PLC-beta2 and -delta [2].
These results suggest that the extracellular signals that induce the dissociation of G(o) or Gi, the heterotrimeric G proteins abundant in brain, should enhance the hydrolysis of PtdIns 4,5-P2 in brain primarily through activation of PLC-beta 3 (PLC-beta 2 is not detectable in brain) [3].
Phospholipase C beta 2 in vascular smooth muscle [4].
This is the first report of phospholipase C beta 2 in tissues other than HL60 cells [4].
Since G proteins activate IP3 production via stimulation of phospholipase C beta isoforms in many tissues, and agonist-stimulated IP3 production in smooth muscle requires G protein activation, phospholipase C beta 2 may be required for agonist-stimulated force production in vascular smooth muscle [4].

Chemical compound and disease context of Plcb2

Calcitriol increases InsP(3) formation via activation of phospholipase C (PLC)-beta1 linked to a pertussis toxin (PTX)-insensitive G-protein, and estradiol via activation of PLC-beta2 linked to a PTX-sensitive G-protein [5].

Biological context of Plcb2

These data indicate that a phospholipase C beta2 isoform mediates a denatonium benzoate-induced second messenger response of taste sensory cells in the circumvallate papillae [6].

Anatomical context of Plcb2

Western blot analysis of pancreatic acinar membranes revealed the presence of PLC-beta 1, -beta 3, -gamma 1, and -delta 1, but not of PLC-beta 2, -beta 4, -gamma 2, and -delta 2 [7].
In SLSE, immunoblotting showed the presence of alpha-gustducin and phospholipase C beta2 (PLCbeta2), which are two markers of chemoreceptor cells [8].

Associations of Plcb2 with chemical compounds

This bitter agent elicited a rapid and transient increase of the inositol 1,4,5-trisphosphate level; this response was blocked by U73122, a potent inhibitor of PLC, and by PLC beta2-specific antibodies [6].

Other interactions of Plcb2

RESULTS: These reverse transcriptase-polymerase chain reaction studies have confirmed expression of the phospholipase C-beta1a, phospholipase C-beta3, phospholipase C-gamma1, phospholipase C-beta2, and phospholipase C-delta1 isoforms in rat myometrial tissue [9].

References

Phospholipase C beta and membrane action of calcitriol and estradiol. Le Mellay, V., Grosse, B., Lieberherr, M. J. Biol. Chem. (1997) [Pubmed]
Requirement of aldose reductase for the hyperglycemic activation of protein kinase C and formation of diacylglycerol in vascular smooth muscle cells. Ramana, K.V., Friedrich, B., Tammali, R., West, M.B., Bhatnagar, A., Srivastava, S.K. Diabetes (2005) [Pubmed]
Activation of phospholipase C isozymes by G protein beta gamma subunits. Park, D., Jhon, D.Y., Lee, C.W., Lee, K.H., Rhee, S.G. J. Biol. Chem. (1993) [Pubmed]
Phospholipase C beta 2 in vascular smooth muscle. LaBelle, E.F., Polyák, F. J. Cell. Physiol. (1996) [Pubmed]
Galpha(q/11) and gbetagamma proteins and membrane signaling of calcitriol and estradiol. Le Mellay, V., Lasmoles, F., Lieberherr, M. J. Cell. Biochem. (1999) [Pubmed]
Identification of a phospholipase C beta subtype in rat taste cells. Rössler, P., Kroner, C., Freitag, J., Noè, J., Breer, H. Eur. J. Cell Biol. (1998) [Pubmed]
CCK, carbachol, and bombesin activate distinct PLC-beta isoenzymes via Gq/11 in rat pancreatic acinar membranes. Piiper, A., Stryjek-Kaminska, D., Klengel, R., Zeuzem, S. Am. J. Physiol. (1997) [Pubmed]
Identification and characterization of a specific sensory epithelium in the rat larynx. Sbarbati, A., Merigo, F., Benati, D., Tizzano, M., Bernardi, P., Crescimanno, C., Osculati, F. J. Comp. Neurol. (2004) [Pubmed]
Phosphatidylinositol-specific phospholipase C isoform expression in pregnant and nonpregnant rat myometrial tissue. Bieber, E., Stratman, T., Sanseverino, M., Sangueza, J., Phillippe, M. Am. J. Obstet. Gynecol. (1998) [Pubmed]

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