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PHO89  -  Na+/Pi cotransporter, active in early...

Saccharomyces cerevisiae S288c

 
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High impact information on PHO89

  • The response of four upregulated genes, ENA1 (encoding a Na+-ATPase also induced by saline stress) and PHO84, PHO89 and PHO12 (encoding genes upregulated by phosphate starvation), was characterized further [1].
  • The deduced amino acid sequence of TcPHO exhibited 51.6 and 49.8% similarity to the amino acid sequences of PHO89 from Saccharomyces cerevisiae and PHO4 from Neurospora crassa, respectively [2].
  • This protein exhibits significant sequence similarity with the yeast Pho89 protein, which is known to be a Na(+)/Pi co-transporter, although the PTB1 protein carries an additional Gln- and Gly-rich large hydrophilic region in the middle of its primary structure [3].
 

Anatomical context of PHO89

 

Other interactions of PHO89

 

Analytical, diagnostic and therapeutic context of PHO89

  • Studies of the acid phosphatase activity of these strains, as well as promoter sequence analysis, suggest that expression of the PHO89 gene is under the control of the PHO regulatory system [6].

References

  1. The transcriptional response to alkaline pH in Saccharomyces cerevisiae: evidence for calcium-mediated signalling. Serrano, R., Ruiz, A., Bernal, D., Chambers, J.R., Ariño, J. Mol. Microbiol. (2002)
  2. Identification of a high-affinity phosphate transporter gene in a prasinophyte alga, Tetraselmis chui, and its expression under nutrient limitation. Chung, C.C., Hwang, S.P., Chang, J. Appl. Environ. Microbiol. (2003)
  3. Insertional mutagenesis in a homologue of a Pi transporter gene confers arsenate resistance on chlamydomonas. Kobayashi, I., Fujiwara, S., Shimogawara, K., Kaise, T., Usuda, H., Tsuzuki, M. Plant Cell Physiol. (2003)
  4. Phosphate permeases of Saccharomyces cerevisiae. Persson, B.L., Berhe, A., Fristedt, U., Martinez, P., Pattison, J., Petersson, J., Weinander, R. Biochim. Biophys. Acta (1998)
  5. Transcriptional regulation of phosphate-responsive genes in low-affinity phosphate-transporter-defective mutants in Saccharomyces cerevisiae. Auesukaree, C., Homma, T., Kaneko, Y., Harashima, S. Biochem. Biophys. Res. Commun. (2003)
  6. Identification, cloning and characterization of a derepressible Na+-coupled phosphate transporter in Saccharomyces cerevisiae. Martinez, P., Persson, B.L. Mol. Gen. Genet. (1998)
 

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Links

  • Homologues
  • NCBI Gene
  • NCBI SNP
  • iHOP resource
  • SNPedia

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