Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene: TPN1 - Plasma membrane pyridoxine (vitamin B6)...

Saccharomyces cerevisiae

Synonyms: G1370, Transport of pyridoxine protein 1, Vitamin B6 transporter TPN1, YGL186C

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Stolz, J., Paluszynski, J.P.

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Disease relevance of TPN1

Among these, Tpn1, Fur4 and the one encoded by yOR071c were found to contribute significantly to 5-FC toxicity, thus revealing alternative entry routes for 5-FC via other cytosine/adenine permease homologues [1].

High impact information on TPN1

Moreover, expression of TPN1 was regulated and increased with decreasing concentrations of vitamin B6 in the medium [2].
TPN1 mutants lost the ability to utilize extracellular PN, pyridoxal, and pyridoxamine, showing that there is no other transporter for vitamin B6 encoded in the genome [2].
Tpn1p, the plasma membrane vitamin B6 transporter of Saccharomyces cerevisiae [2].
Amino acid substitutions that led to a loss of Tpn1p function localized to transmembrane domain 4 within the 12-transmembrane domain protein [2].

References

Various cytosine/adenine permease homologues are involved in the toxicity of 5-fluorocytosine in Saccharomyces cerevisiae. Paluszynski, J.P., Klassen, R., Rohe, M., Meinhardt, F. Yeast (2006)
Tpn1p, the plasma membrane vitamin B6 transporter of Saccharomyces cerevisiae. Stolz, J., Vielreicher, M. J. Biol. Chem. (2003)

Gene: TPN1 - Plasma membrane pyridoxine (vitamin B6)...

Saccharomyces cerevisiae

Disease relevance of TPN1

High impact information on TPN1

References

Editor

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