Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

CGR1 - Cgr1p

Saccharomyces cerevisiae S288c

Synonyms: Coiled-coil growth-regulated protein 1, YGL029W, rRNA-processing protein CGR1

Sun, J. et al., Sun, J. et al., Moy, T.I. et al., Cho, T. et al.

Cho, Toyoda, Sudoh, Nakashima, Calderone, Kaminishi,

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High impact information on CGR1

We have reported previously that the expression of CGR1 increased at an early stage of the yeast-mycelial transition (morphogenesis) in Candida albicans [1].
Identification of a role for Saccharomyces cerevisiae Cgr1p in pre-rRNA processing and 60S ribosome subunit synthesis [2].
Together these findings establish a role for Cgr1p in ribosome biogenesis [2].
Saccharomyces cerevisiae CGR1 encodes a 120-amino acid protein with a predominant nucleolar localization [3].
Saccharomyces cerevisiae open reading frame (ORF) YGL029w (CGR1) encodes a small hydrophilic protein of unknown function [4].

Biological context of CGR1

Cells depleted of CGR1 mRNA were growth impaired and hypersensitive to the translational inhibitor paromomycin, and this phenotype was complemented by episomal expression of the CGR1-GFP fusion gene [4].
A plasmid expressing cgrA complemented the impaired growth phenotype of a yeast strain that can be inducibly depleted of CGR1, and a green fluorescent protein (GFP)-tagged CgrA protein had the same nucleolar localization as the corresponding yeast protein [3].
To investigate the role of this gene, we have determined the intracellular localization of the encoded product and examined the effects of Cgr1p depletion on cell growth [4].

Analytical, diagnostic and therapeutic context of CGR1

Molecular cloning of cgrA, the gene encoding the Aspergillus nidulans ortholog of Saccharomyces cerevisiae CGR1 [3].

References

Isolation and sequencing of the Candida albicans MSI3, a putative novel member of the HSP70 family. Cho, T., Toyoda, M., Sudoh, M., Nakashima, Y., Calderone, R.A., Kaminishi, H. Yeast (2003) [Pubmed]
Identification of a role for Saccharomyces cerevisiae Cgr1p in pre-rRNA processing and 60S ribosome subunit synthesis. Moy, T.I., Boettner, D., Rhodes, J.C., Silver, P.A., Askew, D.S. Microbiology (Reading, Engl.) (2002) [Pubmed]
Molecular cloning of cgrA, the gene encoding the Aspergillus nidulans ortholog of Saccharomyces cerevisiae CGR1. Sun, J., Boettner, D., Huebner, N., Xu, F., Rhodes, J.C., Askew, D.S. Curr. Microbiol. (2001) [Pubmed]
Cgr1p, a novel nucleolar protein encoded by Saccharomyces cerevisiae orf YGL0292w. Sun, J., McFarland, M., Boettner, D., Panepinto, J., Rhodes, J.C., Askew, D.S. Curr. Microbiol. (2001) [Pubmed]

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