Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

UTP8 - Utp8p

Saccharomyces cerevisiae S288c

Synonyms: U three protein 8, U3 protein 8 required for transcription, U3 small nucleolar RNA-associated protein 8, U3 snoRNA-associated protein 8, YGR128C, ...

Steiner-Mosonyi, M. et al.

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High impact information on UTP8

Like the S. cerevisiae Los1p and the mammalian exportin-t, which are proteins known to facilitate nuclear tRNA export, overexpression of Utp8p restored export of tRNAamTyr mutants defective in nuclear export [1].
Furthermore, depletion of Utp8p blocked nuclear export of mature tRNAs derived from both intronless and intron-containing pre-tRNAs but did not affect tRNA and rRNA maturation, nuclear export of mRNA and ribosomes, or nuclear tRNA aminoacylation [1].
One of the proteins identified by this strategy is Utp8p, an essential 80-kDa nucleolar protein that has been implicated in 18 S ribosomal RNA biogenesis [1].

References

Utp8p is an essential intranuclear component of the nuclear tRNA export machinery of Saccharomyces cerevisiae. Steiner-Mosonyi, M., Leslie, D.M., Dehghani, H., Aitchison, J.D., Mangroo, D. J. Biol. Chem. (2003) [Pubmed]

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