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SKN1  -  beta-glucan synthesis-associated protein SKN1

Saccharomyces cerevisiae S288c

Synonyms: Beta-glucan synthesis-associated protein SKN1, YGR143W
 
 
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High impact information on SKN1

  • Here we show that despite its distinct mode of target gene recognition, SKN-1 functions similarly to resist oxidative stress in C. elegans [1].
  • During postembryonic stages, SKN-1 regulates a key Phase II detoxification gene through constitutive and stress-inducible mechanisms in the ASI chemosensory neurons and intestine, respectively [1].
  • During the earliest stages of Caenorhabditis elegans embryogenesis, the transcription factor SKN-1 initiates development of the digestive system and other mesendodermal tissues [1].
  • KRE6 and SKN1 are predicted to encode homologous proteins that participate in assembly of the cell wall polymer (1-->6)-beta-glucan [2].
  • These results show that SKN1, together with IPT1, is involved in sphingolipid biosynthesis in S. cerevisiae [3].
 

Biological context of SKN1

 

Anatomical context of SKN1

  • It has been postulated that the synthesis of beta1,6-glucan begins in the endoplasmic reticulum with the formation of protein-bound primer structures and that these primer structures are extended in the Golgi complex by two putative glucosyltransferases that are functionally redundant, Kre6 and Skn1 [4].
 

Associations of SKN1 with chemical compounds

  • Consistent with their direct role in the assembly of this polymer, both Kre6p and Skn1p possess COOH-terminal domains with significant sequence similarity to two recently identified glucan-binding proteins [2].
  • SKN-1 binds to DNA through a unique mechanism, but is distantly related to basic leucine-zipper proteins that orchestrate the major oxidative stress response in vertebrates and yeast [1].
 

Regulatory relationships of SKN1

  • The results of Northern blot analysis revealed that C. albicans KRE6 was expressed at a higher level than SKN1 in the yeast phase, while SKN1 expression was strongly induced upon induction of hyphal formation [5].
 

Other interactions of SKN1

  • In addition, the C. albicans KRE6 and SKN1 mRNAs but not the actin mRNA were shortened during the yeast-hypha transition [5].

References

  1. SKN-1 links C. elegans mesendodermal specification to a conserved oxidative stress response. An, J.H., Blackwell, T.K. Genes Dev. (2003) [Pubmed]
  2. Characterization of the yeast (1-->6)-beta-glucan biosynthetic components, Kre6p and Skn1p, and genetic interactions between the PKC1 pathway and extracellular matrix assembly. Roemer, T., Paravicini, G., Payton, M.A., Bussey, H. J. Cell Biol. (1994) [Pubmed]
  3. SKN1, a novel plant defensin-sensitivity gene in Saccharomyces cerevisiae, is implicated in sphingolipid biosynthesis. Thevissen, K., Idkowiak-Baldys, J., Im, Y.J., Takemoto, J., François, I.E., Ferket, K.K., Aerts, A.M., Meert, E.M., Winderickx, J., Roosen, J., Cammue, B.P. FEBS Lett. (2005) [Pubmed]
  4. Localization of synthesis of beta1,6-glucan in Saccharomyces cerevisiae. Montijn, R.C., Vink, E., Müller, W.H., Verkleij, A.J., Van Den Ende, H., Henrissat, B., Klis, F.M. J. Bacteriol. (1999) [Pubmed]
  5. Isolation of the Candida albicans homologs of Saccharomyces cerevisiae KRE6 and SKN1: expression and physiological function. Mio, T., Yamada-Okabe, T., Yabe, T., Nakajima, T., Arisawa, M., Yamada-Okabe, H. J. Bacteriol. (1997) [Pubmed]
 
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