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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene: AMA1
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Activator of meiotic anaphase promoting...
Saccharomyces cerevisiae
Synonyms: Activator of meiotic APC/C protein 1, G8541, Meiosis-specific APC/C activator protein AMA1, SPO70, Sporulation-specific protein 70, YGR225W
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The yeast APC/C subunit Mnd2 prevents premature sister chromatid separation triggered by the meiosis-specific APC/C-Ama1[1].
The meiosis-specific processing of AMA1 mRNA depends on the previously described MER1 splicing factor [2].
Third, ectopic overexpression of AMA1 is able to stimulate ubiquitination of Clb1p in vitro and degradation of Clb1p in vivo [2].
Mutants lacking AMA1 revealed that it is required for the first meiotic division but not the mitotic-like meiosis II [2].
Here we describe the yeast gene AMA1, a new member of the Cdc20 protein family that regulates the multisubunit ubiquitin ligase termed the anaphase promoting complex/cyclosome (APC/C) [2].
The requirement of Ama1p only for meiosis I and spore morphogenesis suggests a function for APC/C(Ama1) specifically adapted to germ cell development [2].
In conclusion, this study indicates that Ama1p directs a meiotic APC/C that functions solely outside mitotic cell division[2].
During S- and prophase, Mnd2 prevents activation of the APC/C by a meiosis-specific activator called Ama1[1].
The function of Ama1 in regulatingSmk1 is independent of the FEAR network, which promotes exit from mitosis and exit from meiosis I through the Cdc14 phosphatase [3].
To prevent nonnative glycosylation, a conservatively mutagenized PV66/AMA-1 gene (PV66Deltaglyc) lacking N-glycosylation sites was also developed [4].
The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.
