Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

HAL5 - Hal5p

Saccharomyces cerevisiae S288c

Synonyms: Halotolerance protein 5, J0531, Serine/threonine-protein kinase HAL5, YJL165C

Mulet, J.M. et al., Pérez-Valle, J. et al., Thornton, G. et al., Portillo, F. et al.

Serrano, Portillo, Mulet,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on HAL5

We have characterized two partially redundant genes from Saccharomyces cerevisiae, HAL4/SAT4 and HAL5, that encode homologous protein kinases implicated in the regulation of cation uptake [1].
This phenotype is suppressed by the TRK1 and HAL5 genes in high-copy number consistent with a defect in K(+) uptake mediated by the Trk system [2].

Associations of HAL5 with chemical compounds

Other nutrient transporters, such as Can1 (arginine permease), Fur4 (uracil permease), and Hxt1 (low-affinity glucose permease), are also destabilized in the hal4 hal5 mutant under low K+ conditions and, in the case of Can1, are stabilized by high K+ concentrations [3].

Biological context of HAL5

Our data support a role for regulation of membrane potential in adaptation to salt stress that is mediated by the Hal4 and Hal5 kinases [1].
Hal4 shares sequence homology to Hal4 and Hal5 in S. cerevisiae, and previous evidence indicates that these kinases positively regulate the major potassium transporter Trk1,2 and thereby maintain the plasma membrane potential [4].

References

A novel mechanism of ion homeostasis and salt tolerance in yeast: the Hal4 and Hal5 protein kinases modulate the Trk1-Trk2 potassium transporter. Mulet, J.M., Leube, M.P., Kron, S.J., Rios, G., Fink, G.R., Serrano, R. Mol. Cell. Biol. (1999) [Pubmed]
A role for the non-phosphorylated form of yeast Snf1: tolerance to toxic cations and activation of potassium transport. Portillo, F., Mulet, J.M., Serrano, R. FEBS Lett. (2005) [Pubmed]
Key role for intracellular K+ and protein kinases Sat4/Hal4 and Hal5 in the plasma membrane stabilization of yeast nutrient transporters. Pérez-Valle, J., Jenkins, H., Merchan, S., Montiel, V., Ramos, J., Sharma, S., Serrano, R., Yenush, L. Mol. Cell. Biol. (2007) [Pubmed]
A novel pathway determining multidrug sensitivity in Schizosaccharomyces pombe. Thornton, G., Wilkinson, C.R., Toone, W.M., Jones, N. Genes Cells (2005) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use

[search][advanced]