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Gene: PEP8  -  Pep8p

Saccharomyces cerevisiae

Synonyms: Carboxypeptidase Y-deficient protein 8, GRD6, J1152, Vacuolar protein sorting-associated protein 26, Vacuolar protein sorting/targeting protein VPS26, Vacuolar protein-targeting protein 4, VPS26, VPT4, YJL053W
 
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High impact information on PEP8

  • The gene, PEP8, plays a role in the delivery of proteins to the vacuole [1].
  • Immuno-gold electron microscopy indicated that the Pep8p localized to vacuolar membranes [1].
  • Expression of pep8 in human cells retards their progression through the G1 phase of the cell cycle [2].
  • Human orthologs of yeast vacuolar protein sorting proteins Vps26, 29, and 35: assembly into multimeric complexes [3].
  • A bioinformatic analysis of the mouse genome identified an additional transcribed paralog of the Vps26 retromer protein, which we termed Vps26B [4].
 

Associations of PEP8 with chemical compounds

  • Hydrophobic residues and a glycine in this loop are required for integration into the retromer complex and endosomal localization of human Vps26, and for the function of yeast Vps26 in carboxypeptidase Y sorting [5].
 

Other interactions of PEP8

  • These results indicate that the vps26(+), vps29(+) and vps35(+) gene products are required for retrograde transport of SpVps10p from the prevacuolar compartment back to the Golgi in Sch. pombe cells [6].

References

  1. The yeast homolog of H < beta > 58, a mouse gene essential for embryogenesis, performs a role in the delivery of proteins to the vacuole. Bachhawat, A.K., Suhan, J., Jones, E.W. Genes Dev. (1994)
  2. An artificial cell-cycle inhibitor isolated from a combinatorial library. Cohen, B.A., Colas, P., Brent, R. Proc. Natl. Acad. Sci. U.S.A. (1998)
  3. Human orthologs of yeast vacuolar protein sorting proteins Vps26, 29, and 35: assembly into multimeric complexes. Haft, C.R., de la Luz Sierra, M., Bafford, R., Lesniak, M.A., Barr, V.A., Taylor, S.I. Mol. Biol. Cell (2000)
  4. A novel mammalian retromer component, Vps26B. Kerr, M.C., Bennetts, J.S., Simpson, F., Thomas, E.C., Flegg, C., Gleeson, P.A., Wicking, C., Teasdale, R.D. Traffic (2005)
  5. The retromer subunit Vps26 has an arrestin fold and binds Vps35 through its C-terminal domain. Shi, H., Rojas, R., Bonifacino, J.S., Hurley, J.H. Nat. Struct. Mol. Biol. (2006)
  6. Vacuolar protein sorting receptor in Schizosaccharomyces pombe. Iwaki, T., Hosomi, A., Tokudomi, S., Kusunoki, Y., Fujita, Y., Giga-Hama, Y., Tanaka, N., Takegawa, K. Microbiology (Reading, Engl.) (2006)
 
 
 
 
 
 
 
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