Gene Review:
TOR2 - phosphatidylinositol kinase-related...
Saccharomyces cerevisiae S288c
Synonyms:
DRR2, Dominant rapamycin resistance protein 2, PI4-kinase TOR2, PI4K TOR2, Phosphatidylinositol 4-kinase TOR2, ...
- The yeast phosphatidylinositol kinase homolog TOR2 activates RHO1 and RHO2 via the exchange factor ROM2. Schmidt, A., Bickle, M., Beck, T., Hall, M.N. Cell (1997)
- TOR kinase domains are required for two distinct functions, only one of which is inhibited by rapamycin. Zheng, X.F., Florentino, D., Chen, J., Crabtree, G.R., Schreiber, S.L. Cell (1995)
- The TOR signalling pathway controls nuclear localization of nutrient-regulated transcription factors. Beck, T., Hall, M.N. Nature (1999)
- Mammalian RAFT1 kinase domain provides rapamycin-sensitive TOR function in yeast. Alarcon, C.M., Cardenas, M.E., Heitman, J. Genes Dev. (1996)
- TOR2 is required for organization of the actin cytoskeleton in yeast. Schmidt, A., Kunz, J., Hall, M.N. Proc. Natl. Acad. Sci. U.S.A. (1996)
- Tor2 directly phosphorylates the AGC kinase Ypk2 to regulate actin polarization. Kamada, Y., Fujioka, Y., Suzuki, N.N., Inagaki, F., Wullschleger, S., Loewith, R., Hall, M.N., Ohsumi, Y. Mol. Cell. Biol. (2005)
- Receptor internalization in yeast requires the Tor2-Rho1 signaling pathway. deHart, A.K., Schnell, J.D., Allen, D.A., Tsai, J.Y., Hicke, L. Mol. Biol. Cell (2003)
- LST8 negatively regulates amino acid biosynthesis as a component of the TOR pathway. Chen, E.J., Kaiser, C.A. J. Cell Biol. (2003)
- FKBP12-rapamycin target TOR2 is a vacuolar protein with an associated phosphatidylinositol-4 kinase activity. Cardenas, M.E., Heitman, J. EMBO J. (1995)
- Phosphoinositide-specific phospholipase C interacts with phosphatidylinositol kinase homolog TOR2. Lin, H., Choi, J.H., Vancura, A. Biochem. Biophys. Res. Commun. (1998)
- Identification of novel single amino acid changes that result in hyperactivation of the unique GTPase, Rheb, in fission yeast. Urano, J., Comiso, M.J., Guo, L., Aspuria, P.J., Deniskin, R., Tabancay, A.P., Kato-Stankiewicz, J., Tamanoi, F. Mol. Microbiol. (2005)
- Molecular organization of target of rapamycin complex 2. Wullschleger, S., Loewith, R., Oppliger, W., Hall, M.N. J. Biol. Chem. (2005)
- Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control. Loewith, R., Jacinto, E., Wullschleger, S., Lorberg, A., Crespo, J.L., Bonenfant, D., Oppliger, W., Jenoe, P., Hall, M.N. Mol. Cell (2002)
- Partitioning the transcriptional program induced by rapamycin among the effectors of the Tor proteins. Shamji, A.F., Kuruvilla, F.G., Schreiber, S.L. Curr. Biol. (2000)
- An essential gene, ESR1, is required for mitotic cell growth, DNA repair and meiotic recombination in Saccharomyces cerevisiae. Kato, R., Ogawa, H. Nucleic Acids Res. (1994)
- Tor kinases are in distinct membrane-associated protein complexes in Saccharomyces cerevisiae. Wedaman, K.P., Reinke, A., Anderson, S., Yates, J., McCaffery, J.M., Powers, T. Mol. Biol. Cell (2003)
- Genome-wide lethality screen identifies new PI4,5P2 effectors that regulate the actin cytoskeleton. Audhya, A., Loewith, R., Parsons, A.B., Gao, L., Tabuchi, M., Zhou, H., Boone, C., Hall, M.N., Emr, S.D. EMBO J. (2004)
- HEAT repeats mediate plasma membrane localization of Tor2p in yeast. Kunz, J., Schneider, U., Howald, I., Schmidt, A., Hall, M.N. J. Biol. Chem. (2000)