Gene Review:
MYLK2 - myosin light chain kinase 2
Homo sapiens
Synonyms:
KMLC, MLCK, MLCK2, Myosin light chain kinase 2, skeletal/cardiac muscle, skMLCK
- Mutational analysis of the kinase domain of MYLK2 gene in common human cancers. Soung, Y.H., Lee, J.W., Kim, S.Y., Nam, S.W., Park, W.S., Lee, J.Y., Yoo, N.J., Lee, S.H. Pathol. Res. Pract. (2006)
- Absence of the mutation of serine/threonine kinase genes AKT2 and MYLK2 in acute leukemias. Soung, Y.H., Lee, J.W., Kim, S.Y., Nam, S.W., Kim, S.H., Lee, J.Y., Yoo, N.J., Lee, S.H. Eur. J. Haematol. (2006)
- A membrane-permeant peptide that inhibits MLC kinase restores barrier function in in vitro models of intestinal disease. Zolotarevsky, Y., Hecht, G., Koutsouris, A., Gonzalez, D.E., Quan, C., Tom, J., Mrsny, R.J., Turner, J.R. Gastroenterology (2002)
- Effects of modulators of myosin light-chain kinase activity in single smooth muscle cells. Itoh, T., Ikebe, M., Kargacin, G.J., Hartshorne, D.J., Kemp, B.E., Fay, F.S. Nature (1989)
- Structural basis of the intrasteric regulation of myosin light chain kinases. Knighton, D.R., Pearson, R.B., Sowadski, J.M., Means, A.R., Ten Eyck, L.F., Taylor, S.S., Kemp, B.E. Science (1992)
- Rho-kinase--mediated contraction of isolated stress fibers. Katoh, K., Kano, Y., Amano, M., Onishi, H., Kaibuchi, K., Fujiwara, K. J. Cell Biol. (2001)
- P2X1-mediated ERK2 activation amplifies the collagen-induced platelet secretion by enhancing myosin light chain kinase activation. Toth-Zsamboki, E., Oury, C., Cornelissen, H., De Vos, R., Vermylen, J., Hoylaerts, M.F. J. Biol. Chem. (2003)
- Isolation of the cDNA encoding rat skeletal muscle myosin light chain kinase. Sequence and tissue distribution. Roush, C.L., Kennelly, P.J., Glaccum, M.B., Helfman, D.M., Scott, J.D., Krebs, E.G. J. Biol. Chem. (1988)
- Activation of myosin light chain kinase and nitric oxide synthase activities by calmodulin fragments. Persechini, A., McMillan, K., Leakey, P. J. Biol. Chem. (1994)
- Migration of F9 parietal endoderm cells is regulated by the ERK pathway. Hong, T., Grabel, L.B. J. Cell. Biochem. (2006)
- Involvement of ras-regulated Myosin light chain phosphorylation in the captopril effects in spontaneously hypertensive rats. Hu, W.Y., Han, Y.J., Gu, L.Z., Piano, M., de Lanerolle, P. Am. J. Hypertens. (2007)
- Mechanisms of ionomycin-induced endothelial cell barrier dysfunction. Garcia, J.G., Schaphorst, K.L., Shi, S., Verin, A.D., Hart, C.M., Callahan, K.S., Patterson, C.E. Am. J. Physiol. (1997)
- Involvement of the Rho-kinase/myosin light chain kinase pathway on human monocyte chemotaxis induced by ATL-1, an aspirin-triggered lipoxin A4 synthetic analog. Simões, R.L., Fierro, I.M. J. Immunol. (2005)
- Differential regulation of alternatively spliced endothelial cell myosin light chain kinase isoforms by p60(Src). Birukov, K.G., Csortos, C., Marzilli, L., Dudek, S., Ma, S.F., Bresnick, A.R., Verin, A.D., Cotter, R.J., Garcia, J.G. J. Biol. Chem. (2001)
- Histamine-induced phosphorylation of the regulatory light chain of myosin II disrupts the barrier integrity of corneal endothelial cells. Srinivas, S.P., Satpathy, M., Guo, Y., Anandan, V. Invest. Ophthalmol. Vis. Sci. (2006)
- Volume-sensitive myosin phosphorylation in vascular endothelial cells: correlation with Na-K-2Cl cotransport. Klein, J.D., O'Neill, W.C. Am. J. Physiol. (1995)
- Enhanced activation of mitogen-activated protein kinase and myosin light chain kinase by the Pro33 polymorphism of integrin beta 3. Vijayan, K.V., Liu, Y., Dong, J.F., Bray, P.F. J. Biol. Chem. (2003)
- A single human myosin light chain kinase gene (MLCK; MYLK). Lazar, V., Garcia, J.G. Genomics (1999)
- An MLCK-dependent window in late G1 controls S phase entry of proliferating rodent hepatocytes via ERK-p70S6K pathway. Bessard, A., Coutant, A., Rescan, C., Ezan, F., Frémin, C., Courselaud, B., Ilyin, G., Baffet, G. Hepatology (2006)