Gene Review:
SAC1 - phosphatidylinositol-3-phosphatase SAC1
Saccharomyces cerevisiae S288c
Synonyms:
Phosphoinositide phosphatase SAC1, RSD1, Recessive suppressor of secretory defect, YKL212W
- Loss of the homotypic fusion and vacuole protein sorting or golgi-associated retrograde protein vesicle tethering complexes results in gentamicin sensitivity in the yeast Saccharomyces cerevisiae. Wagner, M.C., Molnar, E.E., Molitoris, B.A., Goebl, M.G. Antimicrob. Agents Chemother. (2006)
- A domain of human immunodeficiency virus type 1 Vpr containing repeated H(S/F)RIG amino acid motifs causes cell growth arrest and structural defects. Macreadie, I.G., Castelli, L.A., Hewish, D.R., Kirkpatrick, A., Ward, A.C., Azad, A.A. Proc. Natl. Acad. Sci. U.S.A. (1995)
- Essential role for diacylglycerol in protein transport from the yeast Golgi complex. Kearns, B.G., McGee, T.P., Mayinger, P., Gedvilaite, A., Phillips, S.E., Kagiwada, S., Bankaitis, V.A. Nature (1997)
- Cell growth-dependent coordination of lipid signaling and glycosylation is mediated by interactions between Sac1p and Dpm1p. Faulhammer, F., Konrad, G., Brankatschk, B., Tahirovic, S., Knödler, A., Mayinger, P. J. Cell Biol. (2005)
- INP51, a yeast inositol polyphosphate 5-phosphatase required for phosphatidylinositol 4,5-bisphosphate homeostasis and whose absence confers a cold-resistant phenotype. Stolz, L.E., Kuo, W.J., Longchamps, J., Sekhon, M.K., York, J.D. J. Biol. Chem. (1998)
- Three SAC1-like genes show overlapping patterns of expression in Arabidopsis but are remarkably silent during embryo development. Despres, B., Bouissonnié, F., Wu, H.J., Gomord, V., Guilleminot, J., Grellet, F., Berger, F., Delseny, M., Devic, M. Plant J. (2003)
- SAC1 encodes a regulated lipid phosphoinositide phosphatase, defects in which can be suppressed by the homologous Inp52p and Inp53p phosphatases. Hughes, W.E., Woscholski, R., Cooke, F.T., Patrick, R.S., Dove, S.K., McDonald, N.Q., Parker, P.J. J. Biol. Chem. (2000)
- Role for lipid signaling and the cell integrity MAP kinase cascade in yeast septum biogenesis. Tahirovic, S., Schorr, M., Then, A., Berger, J., Schwarz, H., Mayinger, P. Curr. Genet. (2003)
- SAC1-like domains of yeast SAC1, INP52, and INP53 and of human synaptojanin encode polyphosphoinositide phosphatases. Guo, S., Stolz, L.E., Lemrow, S.M., York, J.D. J. Biol. Chem. (1999)
- Regulation of intracellular phosphatidylinositol-4-phosphate by the Sac1 lipid phosphatase. Tahirovic, S., Schorr, M., Mayinger, P. Traffic (2005)
- SAC1p is an integral membrane protein that influences the cellular requirement for phospholipid transfer protein function and inositol in yeast. Whitters, E.A., Cleves, A.E., McGee, T.P., Skinner, H.B., Bankaitis, V.A. J. Cell Biol. (1993)
- Sac1p of Saccharomyces cerevisiae is not involved in ATP release to the extracellular fluid. Boyum, R., Guidotti, G. Biochem. Biophys. Res. Commun. (1997)
- The complete sequencing of a 24.6 kb segment of yeast chromosome XI identified the known loci URA1, SAC1 and TRP3, and revealed 6 new open reading frames including homologues to the threonine dehydratases, membrane transporters, hydantoinases and the phospholipase A2-activating protein. Tzermia, M., Horaitis, O., Alexandraki, D. Yeast (1994)
- Mutations in the SAC1 gene suppress defects in yeast Golgi and yeast actin function. Cleves, A.E., Novick, P.J., Bankaitis, V.A. J. Cell Biol. (1989)
- The phosphoinositide phosphatase Sac1p controls trafficking of the yeast Chs3p chitin synthase. Schorr, M., Then, A., Tahirovic, S., Hug, N., Mayinger, P. Curr. Biol. (2001)
- Suppressors of yeast actin mutations. Novick, P., Osmond, B.C., Botstein, D. Genetics (1989)
- The MBR1 gene from Saccharomyces cerevisiae is activated by and required for growth under sub-optimal conditions. Reisdorf, P., Boy-Marcotte, E., Bolotin-Fukuhara, M. Mol. Gen. Genet. (1997)
- The yeast inositol polyphosphate 5-phosphatases inp52p and inp53p translocate to actin patches following hyperosmotic stress: mechanism for regulating phosphatidylinositol 4,5-bisphosphate at plasma membrane invaginations. Ooms, L.M., McColl, B.K., Wiradjaja, F., Wijayaratnam, A.P., Gleeson, P., Gething, M.J., Sambrook, J., Mitchell, C.A. Mol. Cell. Biol. (2000)
- Development of plant regeneration and transformation protocols for the desiccation-sensitive weeping lovegrass Eragrostis curvula. Ncanana, S., Brandt, W., Lindsey, G., Farrant, J. Plant Cell Rep. (2005)