Gene Review:
APN1 - DNA-(apurinic or apyrimidinic site) lyase...
Saccharomyces cerevisiae S288c
Synonyms:
AP endonuclease 1, Apurinic-apyrimidinic endonuclease 1, DNA-(apurinic or apyrimidinic site) lyase 1, YKL114C, YKL513
- The Saccharomyces cerevisiae ETH1 gene, an inducible homolog of exonuclease III that provides resistance to DNA-damaging agents and limits spontaneous mutagenesis. Bennett, R.A. Mol. Cell. Biol. (1999)
- Expression of yeast apurinic/apyrimidinic endonuclease (APN1) protects lung epithelial cells from bleomycin toxicity. He, Y.H., Wu, M., Kobune, M., Xu, Y., Kelley, M.R., Martin, W.J. Am. J. Respir. Cell Mol. Biol. (2001)
- Genotoxin resistance properties of transgenic tobacco plants expressing bacteriophage T4 DenV and Saccharomyces cerevisiae Apn1 proteins. Lapointe, G., Winchcombe-Forhan, C., Evans, D.H. Biochem. Cell Biol. (1997)
- Identification of APN2, the Saccharomyces cerevisiae homolog of the major human AP endonuclease HAP1, and its role in the repair of abasic sites. Johnson, R.E., Torres-Ramos, C.A., Izumi, T., Mitra, S., Prakash, S., Prakash, L. Genes Dev. (1998)
- Endogenous DNA abasic sites cause cell death in the absence of Apn1, Apn2 and Rad1/Rad10 in Saccharomyces cerevisiae. Guillet, M., Boiteux, S. EMBO J. (2002)
- Specificity of the mutator caused by deletion of the yeast structural gene (APN1) for the major apurinic endonuclease. Kunz, B.A., Henson, E.S., Roche, H., Ramotar, D., Nunoshiba, T., Demple, B. Proc. Natl. Acad. Sci. U.S.A. (1994)
- In vivo evidence for endogenous DNA alkylation damage as a source of spontaneous mutation in eukaryotic cells. Xiao, W., Samson, L. Proc. Natl. Acad. Sci. U.S.A. (1993)
- Molecular mechanism of base excision repair of uracil-containing DNA in yeast cell-free extracts. Wang, Z., Wu, X., Friedberg, E.C. J. Biol. Chem. (1997)
- Overlapping specificities of base excision repair, nucleotide excision repair, recombination, and translesion synthesis pathways for DNA base damage in Saccharomyces cerevisiae. Swanson, R.L., Morey, N.J., Doetsch, P.W., Jinks-Robertson, S. Mol. Cell. Biol. (1999)
- Abrogation of the Chk1-Pds1 checkpoint leads to tolerance of persistent single-strand breaks in Saccharomyces cerevisiae. Karumbati, A.S., Wilson, T.E. Genetics (2005)
- Effect of S. cerevisiae APN1 protein on mammalian DNA base excision repair. Bogliolo, M., Cappelli, E., D'Osualdo, A., Rossi, O., Barbieri, O., Kelley, M.R., Frosina, G. Anticancer Res. (2003)
- Pir1p mediates translocation of the yeast Apn1p endonuclease into the mitochondria to maintain genomic stability. Vongsamphanh, R., Fortier, P.K., Ramotar, D. Mol. Cell. Biol. (2001)
- The role of yeast DNA 3'-phosphatase Tpp1 and rad1/Rad10 endonuclease in processing spontaneous and induced base lesions. Karumbati, A.S., Deshpande, R.A., Jilani, A., Vance, J.R., Ramotar, D., Wilson, T.E. J. Biol. Chem. (2003)
- 3'-phosphodiesterase and 3'-->5' exonuclease activities of yeast Apn2 protein and requirement of these activities for repair of oxidative DNA damage. Unk, I., Haracska, L., Prakash, S., Prakash, L. Mol. Cell. Biol. (2001)
- Synergism between yeast nucleotide and base excision repair pathways in the protection against DNA methylation damage. Xiao, W., Chow, B.L. Curr. Genet. (1998)
- Use of yeast for detection of endogenous abasic lesions, their source, and their repair. Boiteux, S., Guillet, M. Meth. Enzymol. (2006)
- Repair of DNA strand breaks by the overlapping functions of lesion-specific and non-lesion-specific DNA 3' phosphatases. Vance, J.R., Wilson, T.E. Mol. Cell. Biol. (2001)
- The use of random-breakage mapping to locate the genes APN1 and YUH1 in the Saccharomyces genome, and to determine gene order near the left end of chromosome XI. Game, J., Bell, M., Ramotar, D., Miller, H. Yeast (1994)
- Rapid isolation of any known genes from whole cells of yeast by PCR. Ramotar, D. Mol. Cell. Biochem. (1995)
- Intracellular localization of the Apn1 DNA repair enzyme of Saccharomyces cerevisiae. Nuclear transport signals and biological role. Ramotar, D., Kim, C., Lillis, R., Demple, B. J. Biol. Chem. (1993)
- Yeast oligonucleotide transformation: its mechanism and application to analysis of mutations induced by defined DNA lesions. Negishi, K., Hata, Y., Sanda, K., Hayatsu, H. Nucleic Acids Symp. Ser. (1997)