Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

PHD1 - Phd1p

Saccharomyces cerevisiae S288c

Synonyms: YKL043W, YKL256

Gimeno, C.J. et al., Ward, M.P. et al., Borneman, A.R. et al., Lo, H.J. et al.

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High impact information on PHD1

In Saccharomyces, this switch is controlled by two regulatory proteins, Ste12p and Phd1p [1].
Further analysis of the network showed that the promoters of MGA1 and PHD1 were bound by all of the factors used in this study, identifying them as key target hubs [2].
Dependence on PKA function can be partially relieved by overexpression of a gene, SOK2, whose product has significant homology with several fungal transcription factors (StuA from Aspergillus nidulans and Phd1 from Saccharomyces cerevisiae) that are associated with cellular differentiation and development [3].
Interestingly, PHD1 overexpression enhances pseudohyphal growth in a haploid strain that has the diploid polar budding pattern because of a mutation in the BUD4 gene [4].
In addition, wild-type diploid strains lacking PHD1 undergo pseudohyphal growth when starved for nitrogen [4].

Biological context of PHD1

Overexpression of PHD1 in wild-type haploid strains does not induce pseudohyphal growth [4].
PHD1 maps to chromosome XI and is predicted to encode a 366-amino-acid protein [4].

Analytical, diagnostic and therapeutic context of PHD1

Epitope-tagged PHD1 was localized to the nucleus by indirect immunofluorescence [4].

References

Nonfilamentous C. albicans mutants are avirulent. Lo, H.J., Köhler, J.R., DiDomenico, B., Loebenberg, D., Cacciapuoti, A., Fink, G.R. Cell (1997) [Pubmed]
Target hub proteins serve as master regulators of development in yeast. Borneman, A.R., Leigh-Bell, J.A., Yu, H., Bertone, P., Gerstein, M., Snyder, M. Genes Dev. (2006) [Pubmed]
SOK2 may regulate cyclic AMP-dependent protein kinase-stimulated growth and pseudohyphal development by repressing transcription. Ward, M.P., Gimeno, C.J., Fink, G.R., Garrett, S. Mol. Cell. Biol. (1995) [Pubmed]
Induction of pseudohyphal growth by overexpression of PHD1, a Saccharomyces cerevisiae gene related to transcriptional regulators of fungal development. Gimeno, C.J., Fink, G.R. Mol. Cell. Biol. (1994) [Pubmed]

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