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Gene Review: 

RPT5  -  Rpt5p

Saccharomyces cerevisiae S288c

Synonyms: 26S protease regulatory subunit 6A, O3258, TBP-1, Tat-binding protein homolog 1, YOR117W, ...
 
 
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High impact information on RPT5

  • Furthermore, detailed analysis of a Tbp1 mutant deficient for transcriptional activation by Gal4p revealed that the mutant is defective in interactions with five other proteins involved in the process of transcription [1].
  • The alanine residue is conserved in all Rpt proteins, except Rpt5, but no function has yet been assigned to the region that contains it [2].
  • YTA1 and YTA2 are essential genes in yeast [3].

References

  1. The TATA-binding protein is not an essential target of the transcriptional activators Gal4p and Gcn4p in Saccharomyces cerevisiae. Bongards, C., Chew, B.S., Lehming, N. Biochem. J. (2003) [Pubmed]
  2. Genetic evidence for interaction between components of the yeast 26S proteasome: combination of a mutation in RPN12 (a lid component gene) with mutations in RPT1 (an ATPase gene) causes synthetic lethality. Takeuchi, J., Toh-e, A. Mol. Gen. Genet. (1999) [Pubmed]
  3. Identification of a set of yeast genes coding for a novel family of putative ATPases with high similarity to constituents of the 26S protease complex. Schnall, R., Mannhaupt, G., Stucka, R., Tauer, R., Ehnle, S., Schwarzlose, C., Vetter, I., Feldmann, H. Yeast (1994) [Pubmed]
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