Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene: FKH1 - Fkh1p

Saccharomyces cerevisiae

Synonyms: Fork head protein homolog 1, YIL131C

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Ercan, S., Zhu, G., Sun, K., Hollenhorst, P.C., Kumar, R., et al.

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High impact information on FKH1

The fkh1 fkh2 mutant also displays aberrant regulation of the 'SIC1' cluster, whose member genes are expressed in the M-G1 interval and are involved in mitotic exit [1].
Finally, the fkh1 fkh2 mutant displays a constitutive pseudohyphal morphology, indicating that Fkh1 and Fkh2 may help control the switch to this mode of growth [1].
Saccharomyces forkhead protein Fkh1 regulates donor preference during mating-type switching through the recombination enhancer [2].
Regions A, D, and E each bind in vivo the transcription activator forkhead proteins Fkh1p and Fkh2p and their associated Ndd1p, although there are no adjacent open reading frames (ORFs) [2].
The roles of DNA and Mcm1p interactions in determining the overlapping and distinct functions of the yeast cell cycle regulatory transcription factors Fkh1p and Fkh2p were examined [3].

Biological context of FKH1

Forkhead genes in transcriptional silencing, cell morphology and the cell cycle. Overlapping and distinct functions for FKH1 and FKH2 in Saccharomyces cerevisiae [4].
Forkhead transcription factors, Fkh1p and Fkh2p, collaborate with Mcm1p to control transcription required for M-phase [5].
To explore the molecular mechanisms that connect C. albicans morphogenesis with cell cycle progression, we analyzed CaFKH2, the single homolog of S. cerevisiae FKH1/FKH2 [6].

Physical interactions of FKH1

Here we show that Mcm1 binding is required for both the transcription of the noncoding RNAs and Fkh1 binding [7].

Other interactions of FKH1

Another closely related forkhead protein, Fkh1p, is also recruited to the CLB2 promoter in vivo [5].
FKH1 was isolated as a gene that, when expressed in multiple copies, could substitute for the function of SIR1 in silencing HMRa [4].
We conclude that the role of Mcm1 in RE is to open chromatin around the conserved domains and activate transcription; this facilitates Fkh1 binding and the level of this binding determines the level of donor preference [7].

Analytical, diagnostic and therapeutic context of FKH1

Furthermore, investigation of the relationship between Fkh2 and a related forkhead protein Fkh1 demonstrates that these proteins act in overlapping pathways to regulate cell morphology and cell separation [8].

References

Two yeast forkhead genes regulate the cell cycle and pseudohyphal growth. Zhu, G., Spellman, P.T., Volpe, T., Brown, P.O., Botstein, D., Davis, T.N., Futcher, B. Nature (2000)
Saccharomyces forkhead protein Fkh1 regulates donor preference during mating-type switching through the recombination enhancer. Sun, K., Coïc, E., Zhou, Z., Durrens, P., Haber, J.E. Genes Dev. (2002)
Mechanisms controlling differential promoter-occupancy by the yeast forkhead proteins Fkh1p and Fkh2p: implications for regulating the cell cycle and differentiation. Hollenhorst, P.C., Pietz, G., Fox, C.A. Genes Dev. (2001)
Forkhead genes in transcriptional silencing, cell morphology and the cell cycle. Overlapping and distinct functions for FKH1 and FKH2 in Saccharomyces cerevisiae. Hollenhorst, P.C., Bose, M.E., Mielke, M.R., Müller, U., Fox, C.A. Genetics (2000)
Forkhead transcription factors, Fkh1p and Fkh2p, collaborate with Mcm1p to control transcription required for M-phase. Kumar, R., Reynolds, D.M., Shevchenko, A., Shevchenko, A., Goldstone, S.D., Dalton, S. Curr. Biol. (2000)
A forkhead transcription factor is important for true hyphal as well as yeast morphogenesis in Candida albicans. Bensen, E.S., Filler, S.G., Berman, J. Eukaryotic Cell (2002)
Yeast recombination enhancer is stimulated by transcription activation. Ercan, S., Reese, J.C., Workman, J.L., Simpson, R.T. Mol. Cell. Biol. (2005)
The forkhead protein Fkh2 is a component of the yeast cell cycle transcription factor SFF. Pic, A., Lim, F.L., Ross, S.J., Veal, E.A., Johnson, A.L., Sultan, M.R., West, A.G., Johnston, L.H., Sharrocks, A.D., Morgan, B.A. EMBO J. (2000)