The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.
wikigene or wiki gene protein drug chemical gene disease author authorship tracking evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Gene Review: 

MND2  -  Mnd2p

Saccharomyces cerevisiae

 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text.

Ideally this entry shall become one comprehensive and continuous article. Bulleted lists, for instance, were only used because it is impossible to automatically integrate independent facts into a continuous text.

Much of the current information on this page has been automatically compiled from Pubmed.

This precompiled information serves as a substrate and matrix to embed your contributions, but it is by no means the final word - Homo sapiens can do much better!

WikiGenes is a non-profit and open access community project.

 

 

High impact information on MND2

  • In vitro, Mnd2 inhibits ubiquitination of Pds1 by APC/C-Ama1 but not by other APC/C holo-enzymes [1].
  • The yeast APC/C subunit Mnd2 prevents premature sister chromatid separation triggered by the meiosis-specific APC/C-Ama1 [1].
  • Mnd2, an essential antagonist of the anaphase-promoting complex during meiotic prophase [2].
  • Here we show that Mnd2, a subunit of the anaphase-promoting complex (APC/C) from budding yeast, is essential to prevent premature destruction of cohesion in meiosis [1].
  • We show that Mnd2, a factor known to associate with APC components, prevents premature securin degradation in meiosis by APC(Ama1). mnd2Delta cells lack linear chromosome axes and exhibit precocious sister chromatid separation, but deletion of AMA1 suppresses these defects [2].
 

Biological context of MND2

  • Both Mnd2 and Swm1 were found specifically associated with a highly purified preparation of APC from haploid yeast whole cell extract [3].
 

Other interactions of MND2

  • Previous studies described meiotic defects for mutations in MND2 and SWM1 [3].
  • During S- and prophase, Mnd2 prevents activation of the APC/C by a meiosis-specific activator called Ama1 [1].

References

  1. The yeast APC/C subunit Mnd2 prevents premature sister chromatid separation triggered by the meiosis-specific APC/C-Ama1. Oelschlaegel, T., Schwickart, M., Matos, J., Bogdanova, A., Camasses, A., Havlis, J., Shevchenko, A., Zachariae, W. Cell (2005)
  2. Mnd2, an essential antagonist of the anaphase-promoting complex during meiotic prophase. Penkner, A.M., Prinz, S., Ferscha, S., Klein, F. Cell (2005)
  3. Mnd2 and Swm1 are core subunits of the Saccharomyces cerevisiae anaphase-promoting complex. Hall, M.C., Torres, M.P., Schroeder, G.K., Borchers, C.H. J. Biol. Chem. (2003)
 
 
 
 
 
 
 
[search][advanced]

Editor

Links

Table of contents