Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

IRC24 - Irc24p

Saccharomyces cerevisiae S288c

Synonyms: Benzil reductase ((S)-benzoin forming) IRC24, Increased recombination centers protein 24, YIR036C

Maruyama, R. et al., Maruyama, R. et al.

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Disease relevance of IRC24

The deduced amino acid sequence had marked homologies to the Bacillus subtilis yueD protein (41% identity), the yeast open reading frame YIR036C protein (31%), and the mammalian sepiapterin reductases (28% to 30%), suggesting that benzil reductase is a novel short-chain de-hydrogenases/ reductase [1].

High impact information on IRC24

Asymmetric reduction with B. cereus benzil reductase, yeast YIR036C protein and gerbil sepiapterin reductase will be utilized to produce important chiral compounds [2].
We isolated the genes encoding yeast YIR036C protein and gerbil sepiapterin reductase, and both recombinant proteins also reduced benzil to (S)-benzoin in vitro [2].
B. cereus benzil reductase showed 31% amino acid identity to the yeast open reading frame YIR036C protein and 28-30% to mammalian sepiapterin reductases, sharing the seven residues consensus for the SDR family [2].

References

Isolation and expression of a Bacillus cereus gene encoding benzil reductase. Maruyama, R., Nishizawa, M., Itoi, Y., Ito, S., Inoue, M. Biotechnol. Bioeng. (2001) [Pubmed]
The enzymes with benzil reductase activity conserved from bacteria to mammals. Maruyama, R., Nishizawa, M., Itoi, Y., Ito, S., Inoue, M. J. Biotechnol. (2002) [Pubmed]

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