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Gene Review

CSM3  -  Csm3p

Saccharomyces cerevisiae S288c

Synonyms: Chromosome segregation in meiosis protein 3, YM9796.01, YMR048W
 
 
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High impact information on CSM3

  • Surprisingly, pausing does not require Mrc1, although Tof1 and Csm3 are both important [1].
  • Simultaneous deletions of the TOF1 (or CSM3), and the RRM3 genes restored fork arrest by removing both the fork-releasing and fork-protection activities [2].
  • The Tof1p-Csm3p protein complex counteracts the Rrm3p helicase to control replication termination of Saccharomyces cerevisiae [2].
  • The present work demonstrates that mammalian TIM and its constitutive binding partner, Tipin (ortholog of S.c. Csm3p, S.p. Swi3p), are replisome-associated proteins [3].
 

Biological context of CSM3

  • We now report that efficient repair also requires proteins involved in chromatid cohesion: Csm3; Tof1; Mrc1, and Dcc1 [4].
 

Other interactions of CSM3

  • This observation suggests that Tof1p-Csm3p function differently from MRC1 and the other above-mentioned genes [2].

References

 
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