Gene Review:
MLH1 - mismatch repair ATPase MLH1
Saccharomyces cerevisiae S288c
Synonyms:
DNA mismatch repair protein MLH1, MutL protein homolog 1, PMS2, Post meiotic segregation protein 2, YM8520.16, ...
- Novel dominant mutations in Saccharomyces cerevisiae MSH6. Das Gupta, R., Kolodner, R.D. Nat. Genet. (2000)
- The effect of genetic background on the function of Saccharomyces cerevisiae mlh1 alleles that correspond to HNPCC missense mutations. Wanat, J.J., Singh, N., Alani, E. Hum. Mol. Genet. (2007)
- Functional domains of the Saccharomyces cerevisiae Mlh1p and Pms1p DNA mismatch repair proteins and their relevance to human hereditary nonpolyposis colorectal cancer-associated mutations. Pang, Q., Prolla, T.A., Liskay, R.M. Mol. Cell. Biol. (1997)
- MLH1 mutations differentially affect meiotic functions in Saccharomyces cerevisiae. Hoffmann, E.R., Shcherbakova, P.V., Kunkel, T.A., Borts, R.H. Genetics (2003)
- Purification of eukaryotic MutL homologs from Saccharomyces cerevisiae using self-affinity technology. Hall, M.C., Kunkel, T.A. Protein Expr. Purif. (2001)
- Meiotic arrest and aneuploidy in MLH3-deficient mice. Lipkin, S.M., Moens, P.B., Wang, V., Lenzi, M., Shanmugarajah, D., Gilgeous, A., Thomas, J., Cheng, J., Touchman, J.W., Green, E.D., Schwartzberg, P., Collins, F.S., Cohen, P.E. Nat. Genet. (2002)
- Mammalian MutS homologue 5 is required for chromosome pairing in meiosis. Edelmann, W., Cohen, P.E., Kneitz, B., Winand, N., Lia, M., Heyer, J., Kolodner, R., Pollard, J.W., Kucherlapati, R. Nat. Genet. (1999)
- Requirement for PCNA in DNA mismatch repair at a step preceding DNA resynthesis. Umar, A., Buermeyer, A.B., Simon, J.A., Thomas, D.C., Clark, A.B., Liskay, R.M., Kunkel, T.A. Cell (1996)
- Destabilization of tracts of simple repetitive DNA in yeast by mutations affecting DNA mismatch repair. Strand, M., Prolla, T.A., Liskay, R.M., Petes, T.D. Nature (1993)
- Mlh1 is unique among mismatch repair proteins in its ability to promote crossing-over during meiosis. Hunter, N., Borts, R.H. Genes Dev. (1997)
- Mutations in the MSH3 gene preferentially lead to deletions within tracts of simple repetitive DNA in Saccharomyces cerevisiae. Strand, M., Earley, M.C., Crouse, G.F., Petes, T.D. Proc. Natl. Acad. Sci. U.S.A. (1995)
- Systematic mutagenesis of the Saccharomyces cerevisiae MLH1 gene reveals distinct roles for Mlh1p in meiotic crossing over and in vegetative and meiotic mismatch repair. Argueso, J.L., Kijas, A.W., Sarin, S., Heck, J., Waase, M., Alani, E. Mol. Cell. Biol. (2003)
- Inactivation of DNA mismatch repair by increased expression of yeast MLH1. Shcherbakova, P.V., Hall, M.C., Lewis, M.S., Bennett, S.E., Martin, K.J., Bushel, P.R., Afshari, C.A., Kunkel, T.A. Mol. Cell. Biol. (2001)
- Contributions by MutL homologues Mlh3 and Pms2 to DNA mismatch repair and tumor suppression in the mouse. Chen, P.C., Dudley, S., Hagen, W., Dizon, D., Paxton, L., Reichow, D., Yoon, S.R., Yang, K., Arnheim, N., Liskay, R.M., Lipkin, S.M. Cancer Res. (2005)
- Analysis of yeast pms1, msh2, and mlh1 mutators points to differences in mismatch correction efficiencies between prokaryotic and eukaryotic cells. Yang, Y., Karthikeyan, R., Mack, S.E., Vonarx, E.J., Kunz, B.A. Mol. Gen. Genet. (1999)
- Dual requirement in yeast DNA mismatch repair for MLH1 and PMS1, two homologs of the bacterial mutL gene. Prolla, T.A., Christie, D.M., Liskay, R.M. Mol. Cell. Biol. (1994)
- Dependence on RAD52 and RAD1 for anticancer drug resistance mediated by inactivation of mismatch repair genes. Durant, S.T., Morris, M.M., Illand, M., McKay, H.J., McCormick, C., Hirst, G.L., Borts, R.H., Brown, R. Curr. Biol. (1999)
- Msh2 separation of function mutations confer defects in the initiation steps of mismatch repair. Kijas, A.W., Studamire, B., Alani, E. J. Mol. Biol. (2003)
- Functional studies on the candidate ATPase domains of Saccharomyces cerevisiae MutLalpha. Tran, P.T., Liskay, R.M. Mol. Cell. Biol. (2000)
- DNA binding properties of the yeast Msh2-Msh6 and Mlh1-Pms1 heterodimers. Drotschmann, K., Hall, M.C., Shcherbakova, P.V., Wang, H., Erie, D.A., Brownewell, F.R., Kool, E.T., Kunkel, T.A. Biol. Chem. (2002)
- The Saccharomyces cerevisiae MLH3 gene functions in MSH3-dependent suppression of frameshift mutations. Flores-Rozas, H., Kolodner, R.D. Proc. Natl. Acad. Sci. U.S.A. (1998)
- Ntg2p, a Saccharomyces cerevisiae DNA N-glycosylase/apurinic or apyrimidinic lyase involved in base excision repair of oxidative DNA damage, interacts with the DNA mismatch repair protein Mlh1p. Identification of a Mlh1p binding motif. Gellon, L., Werner, M., Boiteux, S. J. Biol. Chem. (2002)
- Interactions of Exo1p with components of MutLalpha in Saccharomyces cerevisiae. Tran, P.T., Simon, J.A., Liskay, R.M. Proc. Natl. Acad. Sci. U.S.A. (2001)
- Differential ATP binding and intrinsic ATP hydrolysis by amino-terminal domains of the yeast Mlh1 and Pms1 proteins. Hall, M.C., Shcherbakova, P.V., Kunkel, T.A. J. Biol. Chem. (2002)
- Functional specificity of MutL homologs in yeast: evidence for three Mlh1-based heterocomplexes with distinct roles during meiosis in recombination and mismatch correction. Wang, T.F., Kleckner, N., Hunter, N. Proc. Natl. Acad. Sci. U.S.A. (1999)
- Heteroduplex rejection during single-strand annealing requires Sgs1 helicase and mismatch repair proteins Msh2 and Msh6 but not Pms1. Sugawara, N., Goldfarb, T., Studamire, B., Alani, E., Haber, J.E. Proc. Natl. Acad. Sci. U.S.A. (2004)
- Analysis of interactions between mismatch repair initiation factors and the replication processivity factor PCNA. Lee, S.D., Alani, E. J. Mol. Biol. (2006)
- Human MutL homolog (MLH1) function in DNA mismatch repair: a prospective screen for missense mutations in the ATPase domain. Ellison, A.R., Lofing, J., Bitter, G.A. Nucleic Acids Res. (2004)
- High affinity cooperative DNA binding by the yeast Mlh1-Pms1 heterodimer. Hall, M.C., Wang, H., Erie, D.A., Kunkel, T.A. J. Mol. Biol. (2001)