The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.
wikigene or wiki gene protein drug chemical gene disease author authorship tracking evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Gene: ROT1  -  Essential ER membrane protein; may be...

Saccharomyces cerevisiae

Synonyms: Hypothetical 28.9 kDa protein in CLN1-RAD14 intergenic region, YM8325.01, YMR200W
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text.

Ideally this entry shall become one comprehensive and continuous article. Bulleted lists, for instance, were only used because it is impossible to automatically integrate independent facts into a continuous text.

Much of the current information on this page has been automatically compiled from Pubmed.

This precompiled information serves as a substrate and matrix to embed your contributions, but it is by no means the final word - Homo sapiens can do much better!

WikiGenes is a non-profit and open access community project.

 

 

High impact information on ROT1

  • ROT2 encodes glucosidase II, and ROT1 and BIG1 encode novel proteins [1].
  • Deletion of ROT1 caused cell aggregation and an abnormal morphology [2].
  • Although ROT1 is essential for growth of Saccharomyces cerevisiae strain BY4741, the growth of a rot1Delta haploid was partially restored by the addition of 0.6 M sorbitol to the growth medium [2].
  • ROT1 genetically interacted with several ER chaperone genes including KAR2, and the rot1-2 mutation triggered the unfolded protein response [3].
  • Mutation of the ROT1 gene caused defects in cell wall synthesis and lysis of autophagic bodies [4].
 

Biological context of ROT1

 

Anatomical context of ROT1

References

  1. Cell wall integrity modulates RHO1 activity via the exchange factor ROM2. Bickle, M., Delley, P.A., Schmidt, A., Hall, M.N. EMBO J. (1998)
  2. Rot1p of Saccharomyces cerevisiae is a putative membrane protein required for normal levels of the cell wall 1,6-beta-glucan. Machi, K., Azuma, M., Igarashi, K., Matsumoto, T., Fukuda, H., Kondo, A., Ooshima, H. Microbiology (Reading, Engl.) (2004)
  3. Saccharomyces cerevisiae Rot1p Is an ER-Localized Membrane Protein That May Function with BiP/Kar2p in Protein Folding. Takeuchi, M., Kimata, Y., Hirata, A., Oka, M., Kohno, K. J. Biochem. (2006)
  4. Causal links between protein folding in the ER and events along the secretory pathway. Takeuchi, M., Kimata, Y., Kohno, K. Autophagy. (2006)
 
 
 
 
 
 
 
[search][advanced]

Editor

Links

Table of contents