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TAF9  -  TATA-binding protein-associated factor TAF9

Saccharomyces cerevisiae S288c

Synonyms: TAF17, TAFII-17, TAFII20, TBP-associated factor 17 kDa, TBP-associated factor 9, ...
 
 
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High impact information on TAF9

  • In yeast, the TBP-associated factors (TAFs) Taf17, Taf60, and Taf61(68) resemble histones H3, H4, and H2B, respectively [1].
  • However, TAF17-depleted cells maintain Ace1-dependent activation, and they induce de novo activation by heat shock factor in a manner predominantly associated with the activator, not the core promoter [2].
  • The percentage of the yeast genome dependent on each TAF ranges from 3% (TAF2) to 59-61% (TAF9) [3].
  • Based on their predicted molecular weights, these genes have been designated TAF67, TAF61(68), TAF40, TAF23(25), TAF19(FUN81), and TAF17 [4].
  • A yeast taf17 mutant requires the Swi6 transcriptional activator for viability and shows defects in cell cycle-regulated transcription [5].
 

Biological context of TAF9

  • The cell cycle and transcriptional defects caused by taf17(slm7-1) are consistent with the role of TAF(II)s as modulators of transcriptional activation and may reflect a role for TAF17 in regulating activation by SBF and MBF [5].
 

Analytical, diagnostic and therapeutic context of TAF9

  • Complementation and allelism tests showed that SLM7 is allelic with the TAF17 gene, which encodes a histone-like component of the general transcription factor TFIID and the SAGA histone acetyltransferase complex [5].

References

  1. Histone-like TAFs are essential for transcription in vivo. Michel, B., Komarnitsky, P., Buratowski, S. Mol. Cell (1998) [Pubmed]
  2. The histone H3-like TAF is broadly required for transcription in yeast. Moqtaderi, Z., Keaveney, M., Struhl, K. Mol. Cell (1998) [Pubmed]
  3. Systematic analysis of essential yeast TAFs in genome-wide transcription and preinitiation complex assembly. Shen, W.C., Bhaumik, S.R., Causton, H.C., Simon, I., Zhu, X., Jennings, E.G., Wang, T.H., Young, R.A., Green, M.R. EMBO J. (2003) [Pubmed]
  4. Yeast homologues of higher eukaryotic TFIID subunits. Moqtaderi, Z., Yale, J.D., Struhl, K., Buratowski, S. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  5. A yeast taf17 mutant requires the Swi6 transcriptional activator for viability and shows defects in cell cycle-regulated transcription. Macpherson, N., Measday, V., Moore, L., Andrews, B. Genetics (2000) [Pubmed]
 
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