Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

ARK1 - Ark1p

Saccharomyces cerevisiae

Cope, M.J., Henry, K.R., Hopper, N.A., Smythe, E.

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High impact information on ARK1

ARK-1 inhibits LET-23-mediated ovulation, a RAS-independent function [1].
Ark1p and a second yeast protein, Prk1p, contain NH2-terminal kinase domains that are 70% identical [2].
Elevated levels of either Ark1p or Prk1p caused a number of actin and cell morphological defects that were not observed when the kinase-dead versions were overexpressed instead [2].

Biological context of ARK1

Lack of both Ark1p and Prk1p resulted in the formation of large cytoplasmic actin clumps and severe defects in cell growth [2].
The Ark1/Prk1 family of protein kinases. Regulators of endocytosis and the actin skeleton [3].

Other interactions of ARK1

Recently, members of a new kinase family, the Ark/Prk kinases, which include mammalian AAK1 and GAK as well as yeast Prk1p, Ark1p, and Akl1p, were shown to regulate components of the endocytic machinery [4].

Analytical, diagnostic and therapeutic context of ARK1

ARK-1 physically interacts with SEM-5 in the yeast two-hybrid assay [1].

References

ARK-1 inhibits EGFR signaling in C. elegans. Hopper, N.A., Lee, J., Sternberg, P.W. Mol. Cell (2000)
Novel protein kinases Ark1p and Prk1p associate with and regulate the cortical actin cytoskeleton in budding yeast. Cope, M.J., Yang, S., Shang, C., Drubin, D.G. J. Cell Biol. (1999)
The Ark1/Prk1 family of protein kinases. Regulators of endocytosis and the actin skeleton. Smythe, E., Ayscough, K.R. EMBO Rep. (2003)
The actin-regulating kinase Prk1p negatively regulates Scd5p, a suppressor of clathrin deficiency, in actin organization and endocytosis. Henry, K.R., D'Hondt, K., Chang, J.S., Nix, D.A., Cope, M.J., Chan, C.S., Drubin, D.G., Lemmon, S.K. Curr. Biol. (2003)