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Gene Review: 

SNF12  -  Snf12p

Saccharomyces cerevisiae S288c

Synonyms: N3224, SWI/SNF complex component SWP73, SWP73, Transcription regulatory protein SNF12, YNR023W
 
 
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High impact information on SNF12

  • Deletion mutants in the SWP73 gene display phenotypes similar to those of swi and snf mutants, and in addition are temperature-sensitive [1].
  • The extent to which Swp73p is required for assisting transcriptional activation depends on the activator and promoter tested [1].
  • Interestingly, Swp73p is necessary for efficient SWI/SNF recruitment at SNZ1 but not at ARG1, indicating distinct subunit requirements for SWI/SNF recruitment at different genes [2].

References

  1. Essential role of Swp73p in the function of yeast Swi/Snf complex. Cairns, B.R., Levinson, R.S., Yamamoto, K.R., Kornberg, R.D. Genes Dev. (1996) [Pubmed]
  2. Recruitment of SWI/SNF by Gcn4p does not require Snf2p or Gcn5p but depends strongly on SWI/SNF integrity, SRB mediator, and SAGA. Yoon, S., Qiu, H., Swanson, M.J., Hinnebusch, A.G. Mol. Cell. Biol. (2003) [Pubmed]
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