High impact information on INM1

• However, it does not affect regulation of INM1 (encoding inositol monophosphatase), the expression of which is up-regulated by myo-inositol [1].
• INM1 was determined by beta-galactosidase activity in a strain containing the fusion gene INM1-lacZintegrated into the genome [1].
• Unlike all other phospholipid biosynthetic enzyme-encoding genes studied, which contain the UASINO regulatory element, INM1 expression is increased in the presence of inositol [2].
• Both lithium and valproate, which cause a decrease in intracellular inositol, effect a decrease in INM1 expression [2].
• In addition, INM1 expression was repressed during growth in glycerol and derepressed as glucose-grown cells entered stationary [2].

Associations of INM1 with chemical compounds

• It has been shown that lithium inhibits yeast inositol monophosphatase (encoded by INM1 and INM2), and both valproate and lithium reduce intracellular inositol [3].

Other interactions of INM1

• Yeast genes that are affected by both lithium and valproate in the phosphoinositide pathways (INO1 increased over 10-fold, INO2 increased twofold and INM1 decreased about twofold) have been identified [3].

References