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Gene Review: 

EDC3  -  Edc3p

Saccharomyces cerevisiae

 
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High impact information on EDC3

  • In this issue of Molecular Cell, Badis et al. demonstrate that autoregulated destabilization of the RPS28B mRNA is mediated by Edc3p interaction with an Rps28p/3'UTR mRNP complex [1].
  • We show that Edc3p can stimulate mRNA decapping of both unstable and stable mRNAs in yeast when the decapping enzyme is compromised by temperature-sensitive alleles of either the DCP1 or the DCP2 genes [2].
  • Identification of Edc3p as an enhancer of mRNA decapping in Saccharomyces cerevisiae [2].

References

  1. Regulation of mRNA decay: decapping goes solo. Jacobson, A. Mol. Cell (2004)
  2. Identification of Edc3p as an enhancer of mRNA decapping in Saccharomyces cerevisiae. Kshirsagar, M., Parker, R. Genetics (2004)
 
 
 
 
 
 
 
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