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TPA1  -  Tpa1p

Saccharomyces cerevisiae S288c

Synonyms: PKHD-type hydroxylase TPA1, Termination and polyadenylation protein 1, YER049W
 
 
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High impact information on TPA1

  • Consistent with a potential role in regulating poly(A) tail length, Tpa1p was also found to coimmunoprecipitate with the yeast poly(A) binding protein Pab1p [1].
  • These results suggest that Tpa1p is a component of a messenger ribonucleoprotein complex bound to the 3' untranslated region of mRNAs that affects translation termination, deadenylation, and mRNA decay [1].
  • In this report, we show that the Saccharomyces cerevisiae protein Tpa1p (for termination and polyadenylation) influences translation termination efficiency, mRNA poly(A) tail length, and mRNA stability [1].
  • Tpa1p is encoded by the previously uncharacterized open reading frame YER049W [1].
  • Acyl DHAP reductase activity in both wild type and tpa1 cells grown on a nonfermentable carbon source was increased approximately 2-fold over that of glucose-grown cells [2].

References

  1. Tpa1p is part of an mRNP complex that influences translation termination, mRNA deadenylation, and mRNA turnover in Saccharomyces cerevisiae. Keeling, K.M., Salas-Marco, J., Osherovich, L.Z., Bedwell, D.M. Mol. Cell. Biol. (2006) [Pubmed]
  2. Regulation of phosphatidic acid biosynthetic enzymes in Saccharomyces cerevisiae. Minskoff, S.A., Racenis, P.V., Granger, J., Larkins, L., Hajra, A.K., Greenberg, M.L. J. Lipid Res. (1994) [Pubmed]
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