Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

HIS1 - ATP phosphoribosyltransferase, a hexameric...

Saccharomyces cerevisiae

Zang, Y., Hinnebusch, A.G., Pearce, D.A., Nestmann, E.R., Erickson, F.L., et al.

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High impact information on HIS1

The gene is located about 8 kilobase pairs from HIS1 and is present as a single copy in the yeast genome [1].
The HIS1 gene of Saccharomyces cerevisiae encodes ATP phosphoribosyltransferase, the first enzyme in the pathway of histidine biosynthesis [2].
We determined the DNA sequence of the HIS1 region defined by this complementation test [2].
The FCY2 gene was mapped on the right arm of chromosome V close to the HIS1 gene [3].
The his1 gene (chromosome V) of Saccharomyces cerevisiae specifies phosphoribosyl transferase (E.C.2.4.2.17), the first enzyme of histidine biosynthesis [4].

Biological context of HIS1

In the DNA sequence upstream from the 5' termini of HIS1 mRNA we have found four closely related copies of a 9-base pair sequence [2].
The PRO2 gene mapped on chromosome XV tightly linked to cdc66, and the PRO3 gene was located on the right arm of chromosome V between HIS1 and the centromere [5].
Homologous sequence are observed in HIS1, HIS3, and in TRP5 upstream regions between copies of the repeat [6].
Cloning of the Candida albicans HIS1 gene by direct complementation of a C. albicans histidine auxotroph using an improved double-ARS shuttle vector [7].
To verify the diploidy of the selected chromosome V, the HIS1 gene was deleted with a standard KanMX4 knockout DNA cassette [8].

Anatomical context of HIS1

To investigate the possibility of inducing specific chromosome loss by centromere deletion in eukaryotic cells, the yeast diploid strain ZG1, carrying three pairs of heterozygous marker genes (CAN1(S)/can1(R), URA3/Deltaura3, hphMX4/HIS1), widely spread on both arms of chromosome V, was constructed [8].

Other interactions of HIS1

Each of the his1-his7 mutant strains were unable to grow in the presence of elevated levels of Cu, Co, or Ni at nearly neutral pHs, in contrast to His(+) strains, which grew under these conditions [9].
Treatment of S. pombe cells with 3-AT leads to a small increase in the level of the his5 transcript, but no effect is seen on the level of the his1 transcript [10].
All 8 induced 2-5-fold increases in reversion frequencies over background at the trp5 locus--5 of these induced 1.5-3-fold increases at the hom3 locus and 1 induced a doubling at his1 [11].

Analytical, diagnostic and therapeutic context of HIS1

The resulting heterogeneity of the HIS1/KanMX4 markers, together with quantitative PCR and densitometric analysis on chromosome V, confirmed its diploid complement, thereby indicating that an endoreduplication event had taken place [8].

References

Structure of the yeast HOM3 gene which encodes aspartokinase. Rafalski, J.A., Falco, S.C. J. Biol. Chem. (1988)
Repeated DNA sequences upstream from HIS1 also occur at several other co-regulated genes in Saccharomyces cerevisiae. Hinnebusch, A.G., Fink, G.R. J. Biol. Chem. (1983)
The purine-cytosine permease gene of Saccharomyces cerevisiae: primary structure and deduced protein sequence of the FCY2 gene product. Weber, E., Rodriguez, C., Chevallier, M.R., Jund, R. Mol. Microbiol. (1990)
Reversion at the HiS1 locus of yeast. Fogel, S., Lax, C., Hurst, D.D. Genetics (1978)
Gene-enzyme relationships in the proline biosynthetic pathway of Saccharomyces cerevisiae. Tomenchok, D.M., Brandriss, M.C. J. Bacteriol. (1987)
The predicted presence of large helical structural variation in yeast HIS4 upstream region is correlated with general amino acid control on the CYC1 gene. Nussinov, R. J. Biomol. Struct. Dyn. (1985)
Cloning of the Candida albicans HIS1 gene by direct complementation of a C. albicans histidine auxotroph using an improved double-ARS shuttle vector. Pla, J., Pérez-Díaz, R.M., Navarro-García, F., Sánchez, M., Nombela, C. Gene (1995)
Chromosome V loss due to centromere knockout or MAD2-deletion is immediately followed by restitution of homozygous diploidy in Saccharomyces cerevisiae. Zang, Y., Garrè, M., Gjuracic, K., Bruschi, C.V. Yeast (2002)
Toxicity of copper, cobalt, and nickel salts is dependent on histidine metabolism in the yeast Saccharomyces cerevisiae. Pearce, D.A., Sherman, F. J. Bacteriol. (1999)
Characterization of Schizosaccharomyces pombe his1 and his5 cDNAs. Erickson, F.L., Hannig, E.M. Yeast (1995)
Mutagenicity of constituents of pulp and paper mill effluent in growing cells of Saccharomyces cerevisiae. Nestmann, E.R., Lee, E.G. Mutat. Res. (1983)