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Gene: FCY22  -  Fcy22p

Saccharomyces cerevisiae

Synonyms: Cytosine/purine transport protein FCY22, FCYX, Fluorocytosine resistance protein 22, PCP FCY22, Purine-cytosine permease FCY22, Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function, YER060W-A
 
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Disease relevance of FCY22

  • Disruption of either FCY21 or FCY22 resulted in strains displaying low-level resistance, indicating the functional involvement of both gene products in 5-FC toxicity [1].
 

High impact information on FCY22

  • A genome-wide search for cytosine permease homologues identified two uncharacterized candidate genes, designated FCY21 and FCY22, both of which exhibit highest similarity to FCY2 [1].

References

  1. Various cytosine/adenine permease homologues are involved in the toxicity of 5-fluorocytosine in Saccharomyces cerevisiae. Paluszynski, J.P., Klassen, R., Rohe, M., Meinhardt, F. Yeast (2006)
 
 
 
 
 
 
 
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