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Gene Review: 

SER3  -  Ser3p

Saccharomyces cerevisiae S288c

Synonyms: 3-PGDH 1, D-3-phosphoglycerate dehydrogenase 1, YER081W
 
 
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High impact information on SER3

  • We now show that SRG1 transcription is regulated by serine, thereby conferring regulation of SER3, a serine biosynthetic gene [1].
  • However, in striking contrast to activation by Swi/Snf, which requires most Swi/Snf subunits, repression by Swi/Snf at SER3 is dependent primarily on one Swi/Snf component, Snf2 [2].
  • Furthermore, we show that Swi/Snf occupancy at two promoters, PHO84 and SER3, is reduced in hht2-11 mutants [3].
  • Moreover, since phosphoglycerate dehydrogenase activity requires NAD(+) as cofactor, deletion of SER3 and SER33 markedly affected redox metabolism as shown by substrate and product analysis [4].
 

Analytical, diagnostic and therapeutic context of SER3

References

  1. Regulation of an intergenic transcript controls adjacent gene transcription in Saccharomyces cerevisiae. Martens, J.A., Wu, P.Y., Winston, F. Genes Dev. (2005) [Pubmed]
  2. Evidence that Swi/Snf directly represses transcription in S. cerevisiae. Martens, J.A., Winston, F. Genes Dev. (2002) [Pubmed]
  3. Analysis of a mutant histone H3 that perturbs the association of Swi/Snf with chromatin. Duina, A.A., Winston, F. Mol. Cell. Biol. (2004) [Pubmed]
  4. Ser3p (Yer081wp) and Ser33p (Yil074cp) are phosphoglycerate dehydrogenases in Saccharomyces cerevisiae. Albers, E., Laizé, V., Blomberg, A., Hohmann, S., Gustafsson, L. J. Biol. Chem. (2003) [Pubmed]
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