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Gene Review: 

AVT6  -  Avt6p

Saccharomyces cerevisiae S288c

Synonyms: Vacuolar amino acid transporter 6, YER119C
 
 
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High impact information on AVT6

  • Three proteins, AVT3, AVT4, and AVT6, are involved in amino acid efflux from the vacuole and, as such, are the first to be shown directly to transport compounds from the lumen of an acidic intracellular organelle [1].
  • Transport by AVT1 and AVT6 requires ATP for function and is abolished in the presence of nigericin, indicating that the same pH gradient can drive amino acid transport in opposing directions [1].
  • Protein AVT6 is responsible for the efflux of aspartate and glutamate, an activity that would account for their exclusion from vacuoles in vivo [1].

References

  1. A family of yeast proteins mediating bidirectional vacuolar amino acid transport. Russnak, R., Konczal, D., McIntire, S.L. J. Biol. Chem. (2001) [Pubmed]
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