Gene Review:
RSP5 - NEDD4 family E3 ubiquitin-protein ligase
Saccharomyces cerevisiae S288c
Synonyms:
E3 ubiquitin-protein ligase RSP5, MDP1, MUT2, NPI1, Reverses SPT-phenotype protein 5, ...
- Genetic interactions between the ESS1 prolyl-isomerase and the RSP5 ubiquitin ligase reveal opposing effects on RNA polymerase II function. Wu, X., Chang, A., Sudol, M., Hanes, S.D. Curr. Genet. (2001)
- A nonconserved Ala401 in the yeast Rsp5 ubiquitin ligase is involved in degradation of Gap1 permease and stress-induced abnormal proteins. Hoshikawa, C., Shichiri, M., Nakamori, S., Takagi, H. Proc. Natl. Acad. Sci. U.S.A. (2003)
- The NPI-1/NPI-3 (karyopherin alpha) binding site on the influenza a virus nucleoprotein NP is a nonconventional nuclear localization signal. Wang, P., Palese, P., O'Neill, R.E. J. Virol. (1997)
- Functional analysis of the human orthologue of the RSP5-encoded ubiquitin protein ligase, hNedd4, in yeast. Gajewska, B., Shcherbik, N., Oficjalska, D., Haines, D.S., Zoładek, T. Curr. Genet. (2003)
- Substrate-mediated remodeling of methionine transport by multiple ubiquitin-dependent mechanisms in yeast cells. Menant, A., Barbey, R., Thomas, D. EMBO J. (2006)
- The Rsp5 ubiquitin ligase is coupled to and antagonized by the Ubp2 deubiquitinating enzyme. Kee, Y., Lyon, N., Huibregtse, J.M. EMBO J. (2005)
- Bsd2 binds the ubiquitin ligase Rsp5 and mediates the ubiquitination of transmembrane proteins. Hettema, E.H., Valdez-Taubas, J., Pelham, H.R. EMBO J. (2004)
- The C2 domain of the Rsp5 ubiquitin ligase binds membrane phosphoinositides and directs ubiquitination of endosomal cargo. Dunn, R., Klos, D.A., Adler, A.S., Hicke, L. J. Cell Biol. (2004)
- A role for ubiquitination in mitochondrial inheritance in Saccharomyces cerevisiae. Fisk, H.A., Yaffe, M.P. J. Cell Biol. (1999)
- Rsp5 WW domains interact directly with the carboxyl-terminal domain of RNA polymerase II. Chang, A., Cheang, S., Espanel, X., Sudol, M. J. Biol. Chem. (2000)
- NPl1, an essential yeast gene involved in induced degradation of Gap1 and Fur4 permeases, encodes the Rsp5 ubiquitin-protein ligase. Hein, C., Springael, J.Y., Volland, C., Haguenauer-Tsapis, R., André, B. Mol. Microbiol. (1995)
- Characterization of the yeast tricalbins: membrane-bound multi-C2-domain proteins that form complexes involved in membrane trafficking. Creutz, C.E., Snyder, S.L., Schulz, T.A. Cell. Mol. Life Sci. (2004)
- Rsp5p, a new link between the actin cytoskeleton and endocytosis in the yeast Saccharomyces cerevisiae. Kamińska, J., Gajewska, B., Hopper, A.K., Zoładek, T. Mol. Cell. Biol. (2002)
- Localization of the Rsp5p ubiquitin-protein ligase at multiple sites within the endocytic pathway. Wang, G., McCaffery, J.M., Wendland, B., Dupré, S., Haguenauer-Tsapis, R., Huibregtse, J.M. Mol. Cell. Biol. (2001)
- A single PXY motif located within the carboxyl terminus of Spt23p and Mga2p mediates a physical and functional interaction with ubiquitin ligase Rsp5p. Shcherbik, N., Kee, Y., Lyon, N., Huibregtse, J.M., Haines, D.S. J. Biol. Chem. (2004)
- Rsp5 ubiquitin ligase affects isoprenoid pathway and cell wall organization in S. cerevisiae. Kamińska, J., Kwapisz, M., Grabińska, K., Orłowski, J., Boguta, M., Palamarczyk, G., Zoładek, T. Acta Biochim. Pol. (2005)
- Rsp5 ubiquitin-protein ligase mediates DNA damage-induced degradation of the large subunit of RNA polymerase II in Saccharomyces cerevisiae. Beaudenon, S.L., Huacani, M.R., Wang, G., McDonnell, D.P., Huibregtse, J.M. Mol. Cell. Biol. (1999)
- The role of ubiquitin conjugation in glucose-induced proteolysis of Saccharomyces maltose permease. Medintz, I., Jiang, H., Michels, C.A. J. Biol. Chem. (1998)
- The cell wall integrity/remodeling MAPK cascade is involved in glucose activation of the yeast plasma membrane H(+)-ATPase. de la Fuente, N., Portillo, F. Biochim. Biophys. Acta (2000)
- Ubiquitin metabolism affects cellular response to volatile anesthetics in yeast. Wolfe, D., Reiner, T., Keeley, J.L., Pizzini, M., Keil, R.L. Mol. Cell. Biol. (1999)
- The growth of mdp1/rsp5 mutants of Saccharomyces cerevisiae is affected by mutations in the ATP-binding domain of the plasma membrane H+ -ATPase. Kamińska, J., Tobiasz, A., Gniewosz, M., Zoładek, T. Gene (2000)
- Rsp5p is required for ER bound Mga2p120 polyubiquitination and release of the processed/tethered transactivator Mga2p90. Shcherbik, N., Zoladek, T., Nickels, J.T., Haines, D.S. Curr. Biol. (2003)
- Yeast glycogen synthase kinase 3 is involved in protein degradation in cooperation with Bul1, Bul2, and Rsp5. Andoh, T., Hirata, Y., Kikuchi, A. Mol. Cell. Biol. (2000)
- The PY-motif of Bul1 protein is essential for growth of Saccharomyces cerevisiae under various stress conditions. Yashiroda, H., Kaida, D., Toh-e, A., Kikuchi, Y. Gene (1998)
- Direct sorting of the yeast uracil permease to the endosomal system is controlled by uracil binding and Rsp5p-dependent ubiquitylation. Blondel, M.O., Morvan, J., Dupré, S., Urban-Grimal, D., Haguenauer-Tsapis, R., Volland, C. Mol. Biol. Cell (2004)
- PY motifs of Rod1 are required for binding to Rsp5 and for drug resistance. Andoh, T., Hirata, Y., Kikuchi, A. FEBS Lett. (2002)
- The large subunit of RNA polymerase II is a substrate of the Rsp5 ubiquitin-protein ligase. Huibregtse, J.M., Yang, J.C., Beaudenon, S.L. Proc. Natl. Acad. Sci. U.S.A. (1997)
- Domains of the Rsp5 ubiquitin-protein ligase required for receptor-mediated and fluid-phase endocytosis. Dunn, R., Hicke, L. Mol. Biol. Cell (2001)
- The Rsp5 E3 ligase mediates turnover of low affinity phosphate transporters in Saccharomyces cerevisiae. Estrella, L.A., Krishnamurthy, S., Timme, C.R., Hampsey, M. J. Biol. Chem. (2008)
- Pressure-induced differential regulation of the two tryptophan permeases Tat1 and Tat2 by ubiquitin ligase Rsp5 and its binding proteins, Bul1 and Bul2. Abe, F., Iida, H. Mol. Cell. Biol. (2003)
- The mRNA nuclear export factor Hpr1 is regulated by Rsp5-mediated ubiquitylation. Gwizdek, C., Hobeika, M., Kus, B., Ossareh-Nazari, B., Dargemont, C., Rodriguez, M.S. J. Biol. Chem. (2005)
- Mutations altering the mitochondrial-cytoplasmic distribution of Mod5p implicate the actin cytoskeleton and mRNA 3' ends and/or protein synthesis in mitochondrial delivery. Zoladek, T., Vaduva, G., Hunter, L.A., Boguta, M., Go, B.D., Martin, N.C., Hopper, A.K. Mol. Cell. Biol. (1995)
- Ubiquitination mediated by the Npi1p/Rsp5p ubiquitin-protein ligase is required for endocytosis of the yeast uracil permease. Galan, J.M., Moreau, V., Andre, B., Volland, C., Haguenauer-Tsapis, R. J. Biol. Chem. (1996)