Gene Review:
RUNX2 - runt-related transcription factor 2
Homo sapiens
Synonyms:
AML3, Acute myeloid leukemia 3 protein, CBF-alpha-1, CBFA1, CCD, ...
Tetsuro Kobayashi,
Xiao,
Carinci,
Pezzetti,
Yoshikawa,
Chiba,
Otto,
Kazuyasu Ohta,
Calvitti,
Kin,
Yamagishi,
Carinci,
Nakase,
Bellucci,
Sakakura,
Lübbert,
Miyagawa,
Bodo,
Kanegane,
Otto,
Lilli,
Hagiwara,
Balducci,
Stabellini,
Franceschi,
Yazumi,
Nakashima,
Stock,
Ito,
Yates,
Mundlos,
Toyoshi Endo,
Bellocchio,
Ito,
Baroni,
- Functional analysis of RUNX2 mutations in Japanese patients with cleidocranial dysplasia demonstrates novel genotype-phenotype correlations. Yoshida, T., Kanegane, H., Osato, M., Yanagida, M., Miyawaki, T., Ito, Y., Shigesada, K. Am. J. Hum. Genet. (2002)
- Dominance of SOX9 function over RUNX2 during skeletogenesis. Zhou, G., Zheng, Q., Engin, F., Munivez, E., Chen, Y., Sebald, E., Krakow, D., Lee, B. Proc. Natl. Acad. Sci. U.S.A. (2006)
- Transforming growth factor-beta stimulates p300-dependent RUNX3 acetylation, which inhibits ubiquitination-mediated degradation. Jin, Y.H., Jeon, E.J., Li, Q.L., Lee, Y.H., Choi, J.K., Kim, W.J., Lee, K.Y., Bae, S.C. J. Biol. Chem. (2004)
- Frequent downregulation of the runt domain transcription factors RUNX1, RUNX3 and their cofactor CBFB in gastric cancer. Sakakura, C., Hagiwara, A., Miyagawa, K., Nakashima, S., Yoshikawa, T., Kin, S., Nakase, Y., Ito, K., Yamagishi, H., Yazumi, S., Chiba, T., Ito, Y. Int. J. Cancer (2005)
- Impaired intranuclear trafficking of Runx2 (AML3/CBFA1) transcription factors in breast cancer cells inhibits osteolysis in vivo. Javed, A., Barnes, G.L., Pratap, J., Antkowiak, T., Gerstenfeld, L.C., van Wijnen, A.J., Stein, J.L., Lian, J.B., Stein, G.S. Proc. Natl. Acad. Sci. U.S.A. (2005)
- Expression and function of Cbfa-1/Runx2 in thyroid papillary carcinoma cells. Endo, T., Ohta, K., Kobayashi, T. J. Clin. Endocrinol. Metab. (2008)
- Suppression of androgen-independent prostate cancer cell aggressiveness by FTY720: validating Runx2 as a potential antimetastatic drug screening platform. Chua, C.W., Chiu, Y.T., Yuen, H.F., Chan, K.W., Man, K., Wang, X., Ling, M.T., Wong, Y.C. Clin. Cancer Res. (2009)
- Crossed cerebellar diaschisis: analysis of iodine-123-IMP SPECT imaging. Flores, L.G., Futami, S., Hoshi, H., Nagamachi, S., Ohnishi, T., Jinnouchi, S., Watanabe, K. J. Nucl. Med. (1995)
- Fly-like visuomotor responses of a robot using aVLSI motion-sensitive chips. Liu, S.C., Usseglio-Viretta, A. Biological cybernetics. (2001)
- SATB2 is a multifunctional determinant of craniofacial patterning and osteoblast differentiation. Dobreva, G., Chahrour, M., Dautzenberg, M., Chirivella, L., Kanzler, B., Fariñas, I., Karsenty, G., Grosschedl, R. Cell (2006)
- Core-binding factor beta interacts with Runx2 and is required for skeletal development. Yoshida, C.A., Furuichi, T., Fujita, T., Fukuyama, R., Kanatani, N., Kobayashi, S., Satake, M., Takada, K., Komori, T. Nat. Genet. (2002)
- Cbfbeta interacts with Runx2 and has a critical role in bone development. Kundu, M., Javed, A., Jeon, J.P., Horner, A., Shum, L., Eckhaus, M., Muenke, M., Lian, J.B., Yang, Y., Nuckolls, G.H., Stein, G.S., Liu, P.P. Nat. Genet. (2002)
- Tissue-wide expression profiling using cDNA subtraction and microarrays to identify tumor-specific genes. Amatschek, S., Koenig, U., Auer, H., Steinlein, P., Pacher, M., Gruenfelder, A., Dekan, G., Vogl, S., Kubista, E., Heider, K.H., Stratowa, C., Schreiber, M., Sommergruber, W. Cancer Res. (2004)
- Induction of retinoic acid-binding protein in normal and malignant human myeloid cells by retinoic acid in acute promyelocytic leukemia patients. Cornic, M., Delva, L., Guidez, F., Balitrand, N., Degos, L., Chomienne, C. Cancer Res. (1992)
- The use of the L-plastin promoter for adenoviral-mediated, tumor-specific gene expression in ovarian and bladder cancer cell lines. Peng, X.Y., Won, J.H., Rutherford, T., Fujii, T., Zelterman, D., Pizzorno, G., Sapi, E., Leavitt, J., Kacinski, B., Crystal, R., Schwartz, P., Deisseroth, A. Cancer Res. (2001)
- In vitro all-trans retinoic acid (ATRA) sensitivity and cellular retinoic acid binding protein (CRABP) levels in relapse leukemic cells after remission induction by ATRA in acute promyelocytic leukemia. Cornic, M., Delva, L., Castaigne, S., Lefebvre, P., Balitrand, N., Degos, L., Chomienne, C. Leukemia (1994)
- In vitro all-trans retinoic acid (ATRA) sensitivity and cellular retinoic acid binding protein (CRABP) levels in relapse leukemic cells after remission induction by ATRA in acute promyelocytic leukemia. Cornic, M., Delva, L., Castaigne, S., Lefebvre, P., Balitrand, N., Degos, L., Chomienne, C. Leukemia (1994)
- Characterization of a new syndrome that associates craniosynostosis, delayed fontanel closure, parietal foramina, imperforate anus, and skin eruption: CDAGS. Mendoza-Londono, R., Lammer, E., Watson, R., Harper, J., Hatamochi, A., Hatamochi-Hayashi, S., Napierala, D., Hermanns, P., Collins, S., Roa, B.B., Hedge, M.R., Wakui, K., Nguyen, D., Stockton, D.W., Lee, B. Am. J. Hum. Genet. (2005)
- Cooperative interactions between RUNX2 and homeodomain protein-binding sites are critical for the osteoblast-specific expression of the bone sialoprotein gene. Roca, H., Phimphilai, M., Gopalakrishnan, R., Xiao, G., Franceschi, R.T. J. Biol. Chem. (2005)
- Insulin-like growth factor-1 regulates endogenous RUNX2 activity in endothelial cells through a phosphatidylinositol 3-kinase/ERK-dependent and Akt-independent signaling pathway. Qiao, M., Shapiro, P., Kumar, R., Passaniti, A. J. Biol. Chem. (2004)
- Runt-related gene 2 in endothelial cells: inducible expression and specific regulation of cell migration and invasion. Sun, L., Vitolo, M., Passaniti, A. Cancer Res. (2001)
- Microtubule-dependent nuclear-cytoplasmic shuttling of Runx2. Pockwinse, S.M., Rajgopal, A., Young, D.W., Mujeeb, K.A., Nickerson, J., Javed, A., Redick, S., Lian, J.B., van Wijnen, A.J., Stein, J.L., Stein, G.S., Doxsey, S.J. J. Cell. Physiol. (2006)
- Basic fibroblast growth factor autocrine loop controls human osteosarcoma phenotyping and differentiation. Bodo, M., Lilli, C., Bellucci, C., Carinci, P., Calvitti, M., Pezzetti, F., Stabellini, G., Bellocchio, S., Balducci, C., Carinci, F., Baroni, T. Mol. Med. (2002)
- Upstream and downstream targets of RUNX proteins. Otto, F., Lübbert, M., Stock, M. J. Cell. Biochem. (2003)
- Serine phosphorylation of RUNX2 with novel potential functions as negative regulatory mechanisms. Wee, H.J., Huang, G., Shigesada, K., Ito, Y. EMBO Rep. (2002)
- MOZ and MORF histone acetyltransferases interact with the Runt-domain transcription factor Runx2. Pelletier, N., Champagne, N., Stifani, S., Yang, X.J. Oncogene (2002)
- Reconstitution of Runx2/Cbfa1-null cells identifies a requirement for BMP2 signaling through a Runx2 functional domain during osteoblast differentiation. Bae, J.S., Gutierrez, S., Narla, R., Pratap, J., Devados, R., van Wijnen, A.J., Stein, J.L., Stein, G.S., Lian, J.B., Javed, A. J. Cell. Biochem. (2007)
- The mechanisms of uremic serum-induced expression of bone matrix proteins in bovine vascular smooth muscle cells. Chen, N.X., Duan, D., O'Neill, K.D., Wolisi, G.O., Koczman, J.J., Laclair, R., Moe, S.M. Kidney Int. (2006)
- Structural and functional characterization of Runx1, CBF beta, and CBF beta-SMMHC. Zhang, L., Lukasik, S.M., Speck, N.A., Bushweller, J.H. Blood Cells Mol. Dis. (2003)
- A role for fibroblast growth factor receptor-2 in the altered osteoblast phenotype induced by Twist haploinsufficiency in the Saethre-Chotzen syndrome. Guenou, H., Kaabeche, K., Mée, S.L., Marie, P.J. Hum. Mol. Genet. (2005)
- Cell cycle-dependent phosphorylation of the RUNX2 transcription factor by cdc2 regulates endothelial cell proliferation. Qiao, M., Shapiro, P., Fosbrink, M., Rus, H., Kumar, R., Passaniti, A. J. Biol. Chem. (2006)
- Effect of carnosine on runt-related transcription factor-2/core binding factor alpha-1 and Sox9 expressions of human periodontal ligament cells. Ito-Kato, E., Suzuki, N., Maeno, M., Takada, T., Tanabe, N., Takayama, T., Ito, K., Otsuka, K. J. Periodont. Res. (2004)
- Physical interaction of the activator protein-1 factors c-Fos and c-Jun with Cbfa1 for collagenase-3 promoter activation. D'Alonzo, R.C., Selvamurugan, N., Karsenty, G., Partridge, N.C. J. Biol. Chem. (2002)
- Regulation of the osteoblast-specific transcription factor, Runx2: responsiveness to multiple signal transduction pathways. Franceschi, R.T., Xiao, G. J. Cell. Biochem. (2003)
- The bone-specific transcriptional regulator Cbfa1 is a target of mechanical signals in osteoblastic cells. Ziros, P.G., Gil, A.P., Georgakopoulos, T., Habeos, I., Kletsas, D., Basdra, E.K., Papavassiliou, A.G. J. Biol. Chem. (2002)
- Identification of cis and trans-acting transcriptional regulators in chondroinduced fibroblasts from the pre-phenotypic gene expression profile. Yates, K.E. Gene (2006)
- Intimate relationship between TGF-beta/BMP signaling and runt domain transcription factor, PEBP2/CBF. Bae, S.C., Lee, K.S., Zhang, Y.W., Ito, Y. The Journal of bone and joint surgery. American volume. (2001)
- The promyelotic leukemia zinc finger promotes osteoblastic differentiation of human mesenchymal stem cells as an upstream regulator of CBFA1. Ikeda, R., Yoshida, K., Tsukahara, S., Sakamoto, Y., Tanaka, H., Furukawa, K., Inoue, I. J. Biol. Chem. (2005)
- Identification of the core element responsive to runt-related transcription factor 2 in the promoter of human type X collagen gene. Higashikawa, A., Saito, T., Ikeda, T., Kamekura, S., Kawamura, N., Kan, A., Oshima, Y., Ohba, S., Ogata, N., Takeshita, K., Nakamura, K., Chung, U.I., Kawaguchi, H. Arthritis Rheum. (2009)
- Regulation of tissue inhibitor of metalloproteinase 1 gene transcription by RUNX1 and RUNX2. Bertrand-Philippe, M., Ruddell, R.G., Arthur, M.J., Thomas, J., Mungalsingh, N., Mann, D.A. J. Biol. Chem. (2004)
- Identification of an N-terminal transactivation domain of Runx1 that separates molecular function from global differentiation function. Liu, H., Carlsson, L., Grundström, T. J. Biol. Chem. (2006)
- BMP2 Commitment to the Osteogenic Lineage Involves Activation of Runx2 by DLX3 and a Homeodomain Transcriptional Network. Hassan, M.Q., Tare, R.S., Lee, S.H., Mandeville, M., Morasso, M.I., Javed, A., van Wijnen, A.J., Stein, J.L., Stein, G.S., Lian, J.B. J. Biol. Chem. (2006)
- P253R fibroblast growth factor receptor-2 mutation induces RUNX2 transcript variants and calvarial osteoblast differentiation. Baroni, T., Carinci, P., Lilli, C., Bellucci, C., Aisa, M.C., Scapoli, L., Volinia, S., Carinci, F., Pezzetti, F., Calvitti, M., Farina, A., Conte, C., Bodo, M. J. Cell. Physiol. (2005)
- Mutations in the RUNX2 gene in patients with cleidocranial dysplasia. Otto, F., Kanegane, H., Mundlos, S. Hum. Mutat. (2002)
- A RUNX2/PEBP2alpha A/CBFA1 mutation displaying impaired transactivation and Smad interaction in cleidocranial dysplasia. Zhang, Y.W., Yasui, N., Ito, K., Huang, G., Fujii, M., Hanai, J., Nogami, H., Ochi, T., Miyazono, K., Ito, Y. Proc. Natl. Acad. Sci. U.S.A. (2000)
- Association of functionally different RUNX2 P2 promoter alleles with BMD. Doecke, J.D., Day, C.J., Stephens, A.S., Carter, S.L., van Daal, A., Kotowicz, M.A., Nicholson, G.C., Morrison, N.A. J. Bone Miner. Res. (2006)