Gene Review:
CBFA2T3 - core-binding factor, runt domain, alpha...
Homo sapiens
Synonyms:
ETO2, MTG16, MTG8-related protein 2, MTGR2, Myeloid translocation gene on chromosome 16 protein, ...
Kochetkova,
McKenzie,
Bais,
Martin,
Secker,
Seshadri,
Powell,
Hinze,
Gardner,
Spendlove,
O'Callaghan,
Cleton-Jansen,
Cornelisse,
Whitmore,
Crawford,
Kremmidiotis,
Sutherland,
Callen,
Morohoshi,
Mitani,
Mitsuhashi,
Kitabayashi,
Takahashi,
Suzuki,
Munakata,
Ohki,
Lindberg,
Olsson,
Persson,
Olsson,
van Wezel,
Lombaerts,
van Roon,
Philippo,
Baelde,
Szuhai,
Cornelisse,
Cleton-Jansen,
Kondoh,
Nakata,
Furuta,
Hosoda,
Gamou,
Kurosawa,
Kinoshita,
Ohki,
Tomita,
Mori,
- CBFA2T3 (MTG16) is a putative breast tumor suppressor gene from the breast cancer loss of heterozygosity region at 16q24.3. Kochetkova, M., McKenzie, O.L., Bais, A.J., Martin, J.M., Secker, G.A., Seshadri, R., Powell, J.A., Hinze, S.J., Gardner, A.E., Spendlove, H.E., O'Callaghan, N.J., Cleton-Jansen, A.M., Cornelisse, C., Whitmore, S.A., Crawford, J., Kremmidiotis, G., Sutherland, G.R., Callen, D.F. Cancer Res. (2002)
- Myeloid maturation block by AML1-MTG16 is associated with Csf1r epigenetic downregulation. Rossetti, S., Van Unen, L., Touw, I.P., Hoogeveen, A.T., Sacchi, N. Oncogene (2005)
- The Leukemia-associated ETO homologues are differently expressed during hematopoietic differentiation. Lindberg, S.R., Olsson, A., Persson, A.M., Olsson, I. Exp. Hematol. (2005)
- A pediatric case of secondary leukemia associated with t(16;21)(q24;q22) exhibiting the chimeric AML1-MTG16 gene. Kondoh, K., Nakata, Y., Furuta, T., Hosoda, F., Gamou, T., Kurosawa, Y., Kinoshita, A., Ohki, M., Tomita, Y., Mori, T. Leuk. Lymphoma (2002)
- ETO2 coordinates cellular proliferation and differentiation during erythropoiesis. Goardon, N., Lambert, J.A., Rodriguez, P., Nissaire, P., Herblot, S., Thibault, P., Dumenil, D., Strouboulis, J., Romeo, P.H., Hoang, T. EMBO J. (2006)
- The partner gene of AML1 in t(16;21) myeloid malignancies is a novel member of the MTG8(ETO) family. Gamou, T., Kitamura, E., Hosoda, F., Shimizu, K., Shinohara, K., Hayashi, Y., Nagase, T., Yokoyama, Y., Ohki, M. Blood (1998)
- Structure and expression pattern of a human MTG8/ETO family gene, MTGR1. Morohoshi, F., Mitani, S., Mitsuhashi, N., Kitabayashi, I., Takahashi, E., Suzuki, M., Munakata, N., Ohki, M. Gene (2000)
- Aberrant CBFA2T3B gene promoter methylation in breast tumors. Bais, A.J., Gardner, A.E., McKenzie, O.L., Callen, D.F., Sutherland, G.R., Kremmidiotis, G. Mol. Cancer (2004)
- ErbB-4 s80 intracellular domain abrogates ETO2-dependent transcriptional repression. Linggi, B., Carpenter, G. J. Biol. Chem. (2006)
- Sequencing, transcript identification, and quantitative gene expression profiling in the breast cancer loss of heterozygosity region 16q24.3 reveal three potential tumor-suppressor genes. Powell, J.A., Gardner, A.E., Bais, A.J., Hinze, S.J., Baker, E., Whitmore, S., Crawford, J., Kochetkova, M., Spendlove, H.E., Doggett, N.A., Sutherland, G.R., Callen, D.F., Kremmidiotis, G. Genomics (2002)
- ZNF652, A Novel Zinc Finger Protein, Interacts with the Putative Breast Tumor Suppressor CBFA2T3 to Repress Transcription. Kumar, R., Manning, J., Spendlove, H.E., Kremmidiotis, G., McKirdy, R., Lee, J., Millband, D.N., Cheney, K.M., Stampfer, M.R., Dwivedi, P.P., Morris, H.A., Callen, D.F. Mol. Cancer Res. (2006)
- Expression analysis of candidate breast tumour suppressor genes on chromosome 16q. van Wezel, T., Lombaerts, M., van Roon, E.H., Philippo, K., Baelde, H.J., Szuhai, K., Cornelisse, C.J., Cleton-Jansen, A.M. Breast Cancer Res. (2005)