Gene Review:
SOCS1 - suppressor of cytokine signaling 1
Homo sapiens
Synonyms:
CIS1, CISH1, Cish1, JAB, JAK-binding protein, ...
- Impaired IFN-gamma-dependent inflammatory responses in human keratinocytes overexpressing the suppressor of cytokine signaling 1. Federici, M., Giustizieri, M.L., Scarponi, C., Girolomoni, G., Albanesi, C. J. Immunol. (2002)
- Expression of SOCS1 and SOCS3 genes is differentially regulated in breast cancer cells in response to proinflammatory cytokine and growth factor signals. Evans, M.K., Yu, C.R., Lohani, A., Mahdi, R.M., Liu, X., Trzeciak, A.R., Egwuagu, C.E. Oncogene (2007)
- Differential hypermethylation of SOCS genes in ovarian and breast carcinomas. Sutherland, K.D., Lindeman, G.J., Choong, D.Y., Wittlin, S., Brentzell, L., Phillips, W., Campbell, I.G., Visvader, J.E. Oncogene (2004)
- SOCS1 and SOCS3 are targeted by hepatitis C virus core/gC1qR ligation to inhibit T-cell function. Yao, Z.Q., Waggoner, S.N., Cruise, M.W., Hall, C., Xie, X., Oldach, D.W., Hahn, Y.S. J. Virol. (2005)
- SOCS1-negative feedback of STAT1 activation is a key pathway in the dsRNA-induced innate immune response of human keratinocytes. Dai, X., Sayama, K., Yamasaki, K., Tohyama, M., Shirakata, Y., Hanakawa, Y., Tokumaru, S., Yahata, Y., Yang, L., Yoshimura, A., Hashimoto, K. J. Invest. Dermatol. (2006)
- SOCS1 silencing enhances antitumor activity of type I IFNs by regulating apoptosis in neuroendocrine tumor cells. Zitzmann, K., Brand, S., De Toni, E.N., Baehs, S., Göke, B., Meinecke, J., Spöttl, G., Meyer, H.H., Auernhammer, C.J. Cancer Res. (2007)
- Methylation of SOCS-3 and SOCS-1 in the carcinogenesis of Barrett's adenocarcinoma. Tischoff, I., Hengge, U.R., Vieth, M., Ell, C., Stolte, M., Weber, A., Schmidt, W.E., Tannapfel, A. Gut (2007)
- Negative regulation of cytokine signaling pathways. Yasukawa, H., Sasaki, A., Yoshimura, A. Annu. Rev. Immunol. (2000)
- SOCS-1, a negative regulator of the JAK/STAT pathway, is silenced by methylation in human hepatocellular carcinoma and shows growth-suppression activity. Yoshikawa, H., Matsubara, K., Qian, G.S., Jackson, P., Groopman, J.D., Manning, J.E., Harris, C.C., Herman, J.G. Nat. Genet. (2001)
- SOCS1 deficiency causes a lymphocyte-dependent perinatal lethality. Marine, J.C., Topham, D.J., McKay, C., Wang, D., Parganas, E., Stravopodis, D., Yoshimura, A., Ihle, J.N. Cell (1999)
- Aberrant methylation of suppressor of cytokine signalling-1 (SOCS-1) gene in pancreatic ductal neoplasms. Fukushima, N., Sato, N., Sahin, F., Su, G.H., Hruban, R.H., Goggins, M. Br. J. Cancer (2003)
- The SOCS box of SOCS-1 accelerates ubiquitin-dependent proteolysis of TEL-JAK2. Kamizono, S., Hanada, T., Yasukawa, H., Minoguchi, S., Kato, R., Minoguchi, M., Hattori, K., Hatakeyama, S., Yada, M., Morita, S., Kitamura, T., Kato, H., Nakayama Ki, n.u.l.l., Yoshimura, A. J. Biol. Chem. (2001)
- CXCR4-mediated suppressor of cytokine signaling up-regulation inactivates growth hormone function. Garzón, R., Soriano, S.F., Rodríguez-Frade, J.M., Gómez, L., Martín de Ana, A., Sánchez-Gómez, M., Martínez-A, C., Mellado, M. J. Biol. Chem. (2004)
- Suppressors of cytokine signaling (SOCS) 1 and SOCS3 interact with and modulate fibroblast growth factor receptor signaling. Ben-Zvi, T., Yayon, A., Gertler, A., Monsonego-Ornan, E. J. Cell. Sci. (2006)
- Radiation hybrid and cytogenetic mapping of SOCS1 and SOCS2 to chromosomes 16p13 and 12q, respectively. Yandava, C.N., Pillari, A., Drazen, J.M. Genomics (1999)
- The suppressor of cytokine signaling-1 (SOCS1) is a novel therapeutic target for enterovirus-induced cardiac injury. Yasukawa, H., Yajima, T., Duplain, H., Iwatate, M., Kido, M., Hoshijima, M., Weitzman, M.D., Nakamura, T., Woodard, S., Xiong, D., Yoshimura, A., Chien, K.R., Knowlton, K.U. J. Clin. Invest. (2003)
- JAB/SOCS1/SSI-1 is an interleukin-2-induced inhibitor of IL-2 signaling. Sporri, B., Kovanen, P.E., Sasaki, A., Yoshimura, A., Leonard, W.J. Blood (2001)
- Identification of suppressors of cytokine signaling (SOCS) proteins in human gestational tissues: differential regulation is associated with the onset of labor. Blumenstein, M., Bowen-Shauver, J.M., Keelan, J.A., Mitchell, M.D. J. Clin. Endocrinol. Metab. (2002)
- SOCS-1, a negative regulator of cytokine signaling, is frequently silenced by methylation in multiple myeloma. Galm, O., Yoshikawa, H., Esteller, M., Osieka, R., Herman, J.G. Blood (2003)
- Interaction of human suppressor of cytokine signaling (SOCS)-2 with the insulin-like growth factor-I receptor. Dey, B.R., Spence, S.L., Nissley, P., Furlanetto, R.W. J. Biol. Chem. (1998)
- Wear debris inhibition of anti-osteoclastogenic signaling by interleukin-6 and interferon-gamma. Mechanistic insights and implications for periprosthetic osteolysis. Rakshit, D.S., Ly, K., Sengupta, T.K., Nestor, B.J., Sculco, T.P., Ivashkiv, L.B., Purdue, P.E. The Journal of bone and joint surgery. American volume. (2006)
- Ethanol metabolism alters interferon gamma signaling in recombinant HepG2 cells. Osna, N.A., Clemens, D.L., Donohue, T.M. Hepatology (2005)
- STAT6 and Ets-1 form a stable complex that modulates Socs-1 expression by interleukin-4 in keratinocytes. Travagli, J., Letourneur, M., Bertoglio, J., Pierre, J. J. Biol. Chem. (2004)
- COMMD1 promotes the ubiquitination of NF-kappaB subunits through a cullin-containing ubiquitin ligase. Maine, G.N., Mao, X., Komarck, C.M., Burstein, E. EMBO J. (2007)
- Regulation of Jak2 through the ubiquitin-proteasome pathway involves phosphorylation of Jak2 on Y1007 and interaction with SOCS-1. Ungureanu, D., Saharinen, P., Junttila, I., Hilton, D.J., Silvennoinen, O. Mol. Cell. Biol. (2002)
- SOCS1 inhibits tumor necrosis factor-induced activation of ASK1-JNK inflammatory signaling by mediating ASK1 degradation. He, Y., Zhang, W., Zhang, R., Zhang, H., Min, W. J. Biol. Chem. (2006)
- The janus kinase inhibitor, Jab/SOCS-1, is an interferon-gamma inducible gene and determines the sensitivity to interferons. Sakamoto, H., Kinjyo, I., Yoshimura, A. Leuk. Lymphoma (2000)
- SOCS-1/JAB/SSI-1 can bind to and suppress Tec protein-tyrosine kinase. Ohya, K., Kajigaya, S., Yamashita, Y., Miyazato, A., Hatake, K., Miura, Y., Ikeda, U., Shimada, K., Ozawa, K., Mano, H. J. Biol. Chem. (1997)
- Estrogen inhibits GH signaling by suppressing GH-induced JAK2 phosphorylation, an effect mediated by SOCS-2. Leung, K.C., Doyle, N., Ballesteros, M., Sjogren, K., Watts, C.K., Low, T.H., Leong, G.M., Ross, R.J., Ho, K.K. Proc. Natl. Acad. Sci. U.S.A. (2003)
- Downregulation of IL-6-induced STAT3 tyrosine phosphorylation by TGF-beta1 is mediated by caspase-dependent and -independent processes. Wierenga, A.T., Schuringa, J.J., Eggen, B.J., Kruijer, W., Vellenga, E. Leukemia (2002)
- SOCS-3 is frequently methylated in head and neck squamous cell carcinoma and its precursor lesions and causes growth inhibition. Weber, A., Hengge, U.R., Bardenheuer, W., Tischoff, I., Sommerer, F., Markwarth, A., Dietz, A., Wittekind, C., Tannapfel, A. Oncogene (2005)
- Structural basis for phosphotyrosine recognition by suppressor of cytokine signaling-3. Bergamin, E., Wu, J., Hubbard, S.R. Structure (2006)
- SOCS1 methylation in patients with newly diagnosed acute myeloid leukemia. Chen, C.Y., Tsay, W., Tang, J.L., Shen, H.L., Lin, S.W., Huang, S.Y., Yao, M., Chen, Y.C., Shen, M.C., Wang, C.H., Tien, H.F. Genes Chromosomes Cancer (2003)
- An alternative and effective HIV vaccination approach based on inhibition of antigen presentation attenuators in dendritic cells. Song, X.T., Evel-Kabler, K., Rollins, L., Aldrich, M., Gao, F., Huang, X.F., Chen, S.Y. PLoS Med. (2006)