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Gene Review

EIF3B  -  eukaryotic translation initiation factor 3...

Homo sapiens

Synonyms: EIF3-ETA, EIF3-P110, EIF3-P116, EIF3S9, Eukaryotic translation initiation factor 3 subunit 9, ...
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High impact information on EIF3S9

  • In the fungus Pneumocystis carinii, at least three gene families (PRT1, MSR, and MSG) have the potential to generate high-frequency antigenic variation, which is likely to be a strategy by which this parasitic fungus is able to prolong its survival in the rat lung [1].
  • Unlike the case for Pneumocystis carinii, in which the homologous PRT-1 genes are multicopy, kex1 is a single-copy gene encoding a protein homologous to fungal serine endoproteases, which localize to the Golgi apparatus [2].
  • By performing a two-hybrid screen with Int-6 as bait, we have isolated subunits belonging to all three complexes, namely eIF3-p110, Rpt4, CSN3 and CSN6 [3].
  • The different copies of the PRT1 genes showed nucleotide sequence heterogeneity, the highest level of divergence being in the proline-rich domain, which varied in both length and composition [4].
  • Copies of multi-gene family, named PRT1 (protease 1), encoding a subtilisin-like serine protease were cloned from the opportunistic fungal pathogen Pneumocystis carinii [4].

Biological context of EIF3S9

  • Prt1 lacks long terminal repeats, having instead short (54 bp) terminal inverted repeats [5].
  • Two open reading frames are found within Prt1 [5].
  • A single copy of Prt1 was detected in the genome of P. blakesleeanus [5].
  • Karyotypic analysis showed that PRT1 was a multi-gene family, copies of which were present on all but one of the P. carinii f. sp. carinii chromosomes [4].
  • Comparison of the nucleotide sequence of a genomic clone and a cDNA clone of PRT1 from P. carinii f. sp. carinii revealed the presence of seven short introns [4].

Anatomical context of EIF3S9

  • While in parts congruent to the plastid TRNK intron phylogeny, a higher divergence of some sequences in PRT1 and in the previously reported, non cpDNA dataset indicates that remnants of an older species stock persisted east of Wallace's line and on the Sunda Shelf [6].

Associations of EIF3S9 with chemical compounds

  • Some copies of PRT1 were contiguous with genes encoding the P. carinii major surface glycoprotein [4].


  1. Gene arrays at Pneumocystis carinii telomeres. Keely, S.P., Renauld, H., Wakefield, A.E., Cushion, M.T., Smulian, A.G., Fosker, N., Fraser, A., Harris, D., Murphy, L., Price, C., Quail, M.A., Seeger, K., Sharp, S., Tindal, C.J., Warren, T., Zuiderwijk, E., Barrell, B.G., Stringer, J.R., Hall, N. Genetics (2005) [Pubmed]
  2. A single-copy gene encodes Kex1, a serine endoprotease of Pneumocystis jiroveci. Kutty, G., Kovacs, J.A. Infect. Immun. (2003) [Pubmed]
  3. Association of the mammalian proto-oncoprotein Int-6 with the three protein complexes eIF3, COP9 signalosome and 26S proteasome. Hoareau Alves, K., Bochard, V., Réty, S., Jalinot, P. FEBS Lett. (2002) [Pubmed]
  4. A Pneumocystis carinii multi-gene family with homology to subtilisin-like serine proteases. Lugli, E.B., Allen, A.G., Wakefield, A.E. Microbiology (Reading, Engl.) (1997) [Pubmed]
  5. Prt1, an unusual retrotransposon-like sequence in the fungus Phycomyces blakesleeanus. Ruiz-Pérez, V.L., Murillo, F.J., Torres-Martínez, S. Mol. Gen. Genet. (1996) [Pubmed]
  6. Introduction of a nuclear marker for phylogenetic analysis of nepenthaceae. Meimberg, H., Heubl, G. Plant biology (Stuttgart, Germany) (2006) [Pubmed]
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