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TNK1  -  tyrosine kinase, non-receptor, 1

Homo sapiens

Synonyms: CD38 negative kinase 1, Non-receptor tyrosine-protein kinase TNK1
 
 
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Disease relevance of TNK1

  • The interval from the onset of chest pain to recanalization seen with TNK-t-PA was 208 +/- 10 (SE) minutes compared with 237 +/- 9 minutes seen with alteplase (p = 0.04) [1].
 

High impact information on TNK1

 

Biological context of TNK1

  • Thus, Tnk1 is a novel tyrosine kinase that may be involved in signalling pathways utilized broadly during fetal development, more selectively in adult tissues and in cell of the lymphohematopoietic system [3].
  • The association of Tnk1 with PLC-gamma1 suggests a role for Tnk1 in phospholipid signal transduction [4].
 

Anatomical context of TNK1

  • Hybridization to fetal multi-tissue Northern blots detected several different Tnk1 transcripts in all fetal tissues examined [3].
  • In contrast, a single Tnk1 transcript was detected in only five of 16 adult tissues examined (prostate, testis, ovary, small intestine and colon) [3].
  • Affinity-purified anti-Tnk1 antibodies specifically recognized a 72-kDa protein in Tnk1-transfected COS-1 cells and cells which express Tnk1 mRNA [4].
 

Other interactions of TNK1

 

Analytical, diagnostic and therapeutic context of TNK1

  • Western blot analysis indicated that Tnk1 is expressed in fetal blood cells, but not in any other hematopoietic tissues examined [4].
  • Another new agent is the TNK mutant of t-PA, which also has a prolonged half-life and seems to produce more rapid and complete thrombolysis, as well as less risk of intracranial bleeding than with alteplase in animal models [6].

References

  1. Comparison of rapidity of coronary recanalization in men with tenecteplase versus alteplase in acute myocardial infarction. Binbrek, A.S., Rao, N.S., Neimane, D., Hatou, E., Abdulali, S., Sobel, B.E. Am. J. Cardiol. (2004) [Pubmed]
  2. T-lymphocyte T4 molecule behaves as the receptor for human retrovirus LAV. Klatzmann, D., Champagne, E., Chamaret, S., Gruest, J., Guetard, D., Hercend, T., Gluckman, J.C., Montagnier, L. Nature (1984) [Pubmed]
  3. Tnk1: a novel intracellular tyrosine kinase gene isolated from human umbilical cord blood CD34+/Lin-/CD38- stem/progenitor cells. Hoehn, G.T., Stokland, T., Amin, S., Ramírez, M., Hawkins, A.L., Griffin, C.A., Small, D., Civin, C.I. Oncogene (1996) [Pubmed]
  4. Characterization of the tyrosine kinase Tnk1 and its binding with phospholipase C-gamma1. Felschow, D.M., Civin, C.I., Hoehn, G.T. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  5. Thirty-eight-negative kinase 1 (TNK1) facilitates TNFalpha-induced apoptosis by blocking NF-kappaB activation. Azoitei, N., Brey, A., Busch, T., Fulda, S., Adler, G., Seufferlein, T. Oncogene (2007) [Pubmed]
  6. Molecular biology of plasminogen activators: what are the clinical implications of drug design? Smalling, R.W. Am. J. Cardiol. (1996) [Pubmed]
 
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