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TNFSF13  -  tumor necrosis factor (ligand) superfamily...

Homo sapiens

Synonyms: A proliferation-inducing ligand, APRIL, CD256, TALL-2, TALL2, ...
 
 
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Disease relevance of TNFSF13

 

Psychiatry related information on TNFSF13

  • Subjects were 116 freshman medical students (96% of one class) who completed questionnaires about alcohol use, mood, personality, social relationships, and parental alcohol abuse on the first day of school, and 106 (88% of the class) who responded to the same questionnaires in April of the first year [4].
  • A total of 803 (84%) players from 22 (88%) participating clubs provided details of rugby training, injuries sustained, and physical activity undertaken during the 16 week summer period (26 April to 16 August 1997) and their perceived fitness before the start of the season [5].
  • From September of 1997 through April of 2005, more than 1,000 older persons without known dementia from more than 30 residential facilities across the Chicago metropolitan area agreed to participate [6].
  • The N-Butylcarbamate Derivative of Galantamine Acts as an Allosteric Potentiating Ligand on alpha7 Nicotinic Receptors in Hippocampal Neurons: Clinical Implications for Treatment of Alzheimer's Disease [7].
  • In April, testes and CPL develop rapidly reaching a peak in early May when females are laying eggs, and when most copulations occur [8].
 

High impact information on TNFSF13

  • APRIL is a related factor that shares receptors with BAFF yet appears to play a different biological role [9].
  • Induction of a non-encephalitogenic type 2 T helper-cell autoimmune response in multiple sclerosis after administration of an altered peptide ligand in a placebo-controlled, randomized phase II trial. The Altered Peptide Ligand in Relapsing MS Study Group [10].
  • We show here that dendritic cells up-regulate BLyS and APRIL upon exposure to interferon-alpha, interferon-gamma or CD40 ligand [11].
  • We report that the tumor neurosis factor homolog APRIL (a proliferation-inducing ligand) stimulates in vitro proliferation of primary B and T cells and increases spleen weight due to accumulation of B cells in vivo [12].
  • An article in the April issue of Developmental Cell demonstrates that lineage commitment by mesenchymal stem cells is regulated by shape-induced changes in Rho GTPase activity and cytoskeletal tension [13].
 

Chemical compound and disease context of TNFSF13

 

Biological context of TNFSF13

 

Anatomical context of TNFSF13

  • Although T cell lines bound little APRIL, the ectopic expression of glycosaminoglycan-rich syndecans or glypicans conferred on these cells a high binding capacity that was completely dependent on APRIL's basic sequence [22].
  • Inhibition of BAFF and APRIL, but not BAFF alone, prevented the survival and/or the migration of newly formed plasma cells to the bone marrow [22].
  • APRIL and BAFF were potent survival factors for exogenous cytokine-dependent myeloma cell lines and were autocrine growth factors for the RPMI8226 and L363 autonomously growing cell lines [1].
  • BAFF or APRIL was also involved in the survival of primary myeloma cells cultured with their bone-marrow environment, and protected them from dexamethasone (DEX)-induced apoptosis [1].
  • APRIL secreted by neutrophils accumulated on tumor cells via proteoglycan binding [23].
 

Associations of TNFSF13 with chemical compounds

 

Physical interactions of TNFSF13

  • Substitution of Tyr13 was tolerated for BAFF binding but not APRIL binding [29].
  • BAFF and APRIL bind to BAFF receptor and TACI and are major B-cell survival factors [30].
  • A Phage Display Screen and Binding Studies with Acetylated Low Density Lipoprotein Provide Evidence for the Importance of the Scavenger Receptor Cysteine-rich (SRCR) Domain in the Ligand-binding Function of MARCO [31].
  • Identification of the Hydrophobic Ligand Binding Pocket of the S1P1 Receptor [32].
  • Global disruption of the WASP autoinhibited structure on Cdc42 binding. Ligand displacement as a novel method for monitoring amide hydrogen exchange [33].
 

Regulatory relationships of TNFSF13

 

Other interactions of TNFSF13

  • Altogether, these data suggest that APRIL/BAFF inhibitors may be of clinical value in MM [1].
  • By showing that nonmalignant B cells up-regulate BAFF and APRIL upon stimulation by T cell CD40 ligand, our findings indicate that NHL B cells deregulate an otherwise physiological autocrine survival pathway to evade apoptosis [2].
  • Engineering an APRIL-specific B cell maturation antigen [29].
  • BLyS and APRIL are capable of signaling through TACI to mediate NF-kappaB responses in HEK293 cells [40].
  • In contrast to BLyS, which is known to be cleaved from the cell surface, we found that APRIL is processed intracellularly by furin convertase [25].
 

Analytical, diagnostic and therapeutic context of TNFSF13

References

  1. BAFF and APRIL protect myeloma cells from apoptosis induced by interleukin 6 deprivation and dexamethasone. Moreaux, J., Legouffe, E., Jourdan, E., Quittet, P., Rème, T., Lugagne, C., Moine, P., Rossi, J.F., Klein, B., Tarte, K. Blood (2004) [Pubmed]
  2. Lymphoma B cells evade apoptosis through the TNF family members BAFF/BLyS and APRIL. He, B., Chadburn, A., Jou, E., Schattner, E.J., Knowles, D.M., Cerutti, A. J. Immunol. (2004) [Pubmed]
  3. BLyS and APRIL in rheumatoid arthritis. Seyler, T.M., Park, Y.W., Takemura, S., Bram, R.J., Kurtin, P.J., Goronzy, J.J., Weyand, C.M. J. Clin. Invest. (2005) [Pubmed]
  4. Alcohol use patterns of first-year medical students: II. Psychosocial characteristics associated with drinking level. Clark, D.C., Daugherty, S.R., Zeldow, P.B., Eckenfels, E.J., Silverman, C.M. Alcohol. Clin. Exp. Res. (1986) [Pubmed]
  5. Influence of preseason training, fitness, and existing injury on subsequent rugby injury. Lee, A.J., Garraway, W.M., Arneil, D.W. British journal of sports medicine. (2001) [Pubmed]
  6. The Rush Memory and Aging Project: study design and baseline characteristics of the study cohort. Bennett, D.A., Schneider, J.A., Buchman, A.S., Mendes de Leon, C., Bienias, J.L., Wilson, R.S. Neuroepidemiology. (2005) [Pubmed]
  7. The N-Butylcarbamate Derivative of Galantamine Acts as an Allosteric Potentiating Ligand on alpha7 Nicotinic Receptors in Hippocampal Neurons: Clinical Implications for Treatment of Alzheimer's Disease. Popa, R.V., Pereira, E.F., Lopes, C., Maelicke, A., Albuquerque, E.X. J. Mol. Neurosci. (2006) [Pubmed]
  8. Environmental and endocrine control of reproduction in the song sparrow, Melospiza melodia. I. Temporal organization of the breeding cycle. Wingfield, J.C. Gen. Comp. Endocrinol. (1984) [Pubmed]
  9. BAFF AND APRIL: a tutorial on B cell survival. Mackay, F., Schneider, P., Rennert, P., Browning, J. Annu. Rev. Immunol. (2003) [Pubmed]
  10. Induction of a non-encephalitogenic type 2 T helper-cell autoimmune response in multiple sclerosis after administration of an altered peptide ligand in a placebo-controlled, randomized phase II trial. The Altered Peptide Ligand in Relapsing MS Study Group. Kappos, L., Comi, G., Panitch, H., Oger, J., Antel, J., Conlon, P., Steinman, L. Nat. Med. (2000) [Pubmed]
  11. DCs induce CD40-independent immunoglobulin class switching through BLyS and APRIL. Litinskiy, M.B., Nardelli, B., Hilbert, D.M., He, B., Schaffer, A., Casali, P., Cerutti, A. Nat. Immunol. (2002) [Pubmed]
  12. APRIL and TALL-I and receptors BCMA and TACI: system for regulating humoral immunity. Yu, G., Boone, T., Delaney, J., Hawkins, N., Kelley, M., Ramakrishnan, M., McCabe, S., Qiu, W.R., Kornuc, M., Xia, X.Z., Guo, J., Stolina, M., Boyle, W.J., Sarosi, I., Hsu, H., Senaldi, G., Theill, L.E. Nat. Immunol. (2000) [Pubmed]
  13. Tension precedes commitment-even for a stem cell. Settleman, J. Mol. Cell (2004) [Pubmed]
  14. Glucocorticoid-induced Tumour Necrosis Factor Receptor (GITR) and its Ligand (GITRL) in Atopic Dermatitis. Baumgartner-Nielsen, J., Vestergaard, C., Thestrup-Pedersen, K., Deleuran, M., Deleuran, B. Acta Derm. Venereol. (2006) [Pubmed]
  15. Prospective Antitumor Effects of the Combination of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL) and Cisplatin Against Esophageal Squamous Cell Carcinoma. Kondo, K., Yamasaki, S., Inoue, N., Sugie, T., Teratani, N., Kan, T., Shimada, Y. Surg. Today (2006) [Pubmed]
  16. Multi-institutional phase I/II trial of oral bexarotene in combination with cisplatin and vinorelbine in previously untreated patients with advanced non-small-cell lung cancer. Khuri, F.R., Rigas, J.R., Figlin, R.A., Gralla, R.J., Shin, D.M., Munden, R., Fox, N., Huyghe, M.R., Kean, Y., Reich, S.D., Hong, W.K. J. Clin. Oncol. (2001) [Pubmed]
  17. Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Is Required for Tumor Necrosis Factor {alpha}-Mediated Sensitization of Human Breast Cancer Cells to Chemotherapy. Xu, J., Zhou, J.Y., Wu, G.S. Cancer Res. (2006) [Pubmed]
  18. Functional expression of the human serotonin 5-HT1A receptor in Escherichia coli. Ligand binding properties and interaction with recombinant G protein alpha-subunits. Bertin, B., Freissmuth, M., Breyer, R.M., Schütz, W., Strosberg, A.D., Marullo, S. J. Biol. Chem. (1992) [Pubmed]
  19. Maturation of marginal zone and follicular B cells requires B cell activating factor of the tumor necrosis factor family and is independent of B cell maturation antigen. Schneider, P., Takatsuka, H., Wilson, A., Mackay, F., Tardivel, A., Lens, S., Cachero, T.G., Finke, D., Beermann, F., Tschopp, J. J. Exp. Med. (2001) [Pubmed]
  20. Identification of a novel receptor for B lymphocyte stimulator that is mutated in a mouse strain with severe B cell deficiency. Yan, M., Brady, J.R., Chan, B., Lee, W.P., Hsu, B., Harless, S., Cancro, M., Grewal, I.S., Dixit, V.M. Curr. Biol. (2001) [Pubmed]
  21. EBV-encoded latent membrane protein 1 cooperates with BAFF/BLyS and APRIL to induce T cell-independent Ig heavy chain class switching. He, B., Raab-Traub, N., Casali, P., Cerutti, A. J. Immunol. (2003) [Pubmed]
  22. Identification of proteoglycans as the APRIL-specific binding partners. Ingold, K., Zumsteg, A., Tardivel, A., Huard, B., Steiner, Q.G., Cachero, T.G., Qiang, F., Gorelik, L., Kalled, S.L., Acha-Orbea, H., Rennert, P.D., Tschopp, J., Schneider, P. J. Exp. Med. (2005) [Pubmed]
  23. Neutrophil-derived APRIL concentrated in tumor lesions by proteoglycans correlates with human B-cell lymphoma aggressiveness. Schwaller, J., Schneider, P., Mhawech-Fauceglia, P., McKee, T., Myit, S., Matthes, T., Tschopp, J., Donze, O., Le Gal, F.A., Huard, B. Blood (2007) [Pubmed]
  24. The uncertain glory of APRIL. Medema, J.P., Planelles-Carazo, L., Hardenberg, G., Hahne, M. Cell Death Differ. (2003) [Pubmed]
  25. Biologically active APRIL is secreted following intracellular processing in the Golgi apparatus by furin convertase. López-Fraga, M., Fernández, R., Albar, J.P., Hahne, M. EMBO Rep. (2001) [Pubmed]
  26. Heparan sulfate proteoglycan binding promotes APRIL-induced tumor cell proliferation. Hendriks, J., Planelles, L., de Jong-Odding, J., Hardenberg, G., Pals, S.T., Hahne, M., Spaargaren, M., Medema, J.P. Cell Death Differ. (2005) [Pubmed]
  27. APRIL and BAFF promote increased viability of replicating human B2 cells via mechanism involving cyclooxygenase 2. Mongini, P.K., Inman, J.K., Han, H., Fattah, R.J., Abramson, S.B., Attur, M. J. Immunol. (2006) [Pubmed]
  28. The Major Glycoprotein Allergen from Arachis hypogaea, Ara h 1, Is a Ligand of Dendritic Cell-Specific ICAM-Grabbing Nonintegrin and Acts as a Th2 Adjuvant In Vitro. Shreffler, W.G., Castro, R.R., Kucuk, Z.Y., Charlop-Powers, Z., Grishina, G., Yoo, S., Burks, A.W., Sampson, H.A. J. Immunol. (2006) [Pubmed]
  29. Engineering an APRIL-specific B cell maturation antigen. Patel, D.R., Wallweber, H.J., Yin, J., Shriver, S.K., Marsters, S.A., Gordon, N.C., Starovasnik, M.A., Kelley, R.F. J. Biol. Chem. (2004) [Pubmed]
  30. Survival and proliferation factors of normal and malignant plasma cells. Klein, B., Tarte, K., Jourdan, M., Mathouk, K., Moreaux, J., Jourdan, E., Legouffe, E., De Vos, J., Rossi, J.F. Int. J. Hematol. (2003) [Pubmed]
  31. A Phage Display Screen and Binding Studies with Acetylated Low Density Lipoprotein Provide Evidence for the Importance of the Scavenger Receptor Cysteine-rich (SRCR) Domain in the Ligand-binding Function of MARCO. Chen, Y., Sankala, M., Ojala, J.R., Sun, Y., Tuuttila, A., Isenman, D.E., Tryggvason, K., Pikkarainen, T. J. Biol. Chem. (2006) [Pubmed]
  32. Identification of the Hydrophobic Ligand Binding Pocket of the S1P1 Receptor. Fujiwara, Y., Osborne, D.A., Walker, M.D., Wang, D.A., Bautista, D.A., Liliom, K., Van Brocklyn, J.R., Parrill, A.L., Tigyi, G. J. Biol. Chem. (2007) [Pubmed]
  33. Global disruption of the WASP autoinhibited structure on Cdc42 binding. Ligand displacement as a novel method for monitoring amide hydrogen exchange. Buck, M., Xu, W., Rosen, M.K. Biochemistry (2001) [Pubmed]
  34. Molecular basis of common variable immunodeficiency. Castigli, E., Geha, R.S. J. Allergy Clin. Immunol. (2006) [Pubmed]
  35. A Proliferation-inducing Ligand (APRIL) is Expressed by Astrocytes and is Increased in Multiple Sclerosis. Thangarajh, M., Masterman, T., Hillert, J., Moerk, S., Jonsson, R. Scand. J. Immunol. (2007) [Pubmed]
  36. Selective inhibition of activin receptor-like kinase 5 signaling blocks profibrotic transforming growth factor beta responses in skin fibroblasts. Mori, Y., Ishida, W., Bhattacharyya, S., Li, Y., Platanias, L.C., Varga, J. Arthritis Rheum. (2004) [Pubmed]
  37. Serum Amyloid A Is an Endogenous Ligand That Differentially Induces IL-12 and IL-23. He, R., Shepard, L.W., Chen, J., Pan, Z.K., Ye, R.D. J. Immunol. (2006) [Pubmed]
  38. Chemotherapy enhances TNF-related apoptosis-inducing ligand DISC assembly in HT29 human colon cancer cells. Lacour, S., Micheau, O., Hammann, A., Drouineaud, V., Tschopp, J., Solary, E., Dimanche-Boitrel, M.T. Oncogene (2003) [Pubmed]
  39. Rheumatoid arthritis fibroblast-like synoviocytes express BCMA and are stimulated by APRIL. Nagatani, K., Itoh, K., Nakajima, K., Kuroki, H., Katsuragawa, Y., Mochizuki, M., Aotsuka, S., Mimori, A. Arthritis Rheum. (2007) [Pubmed]
  40. Tumor necrosis factor (TNF) receptor superfamily member TACI is a high affinity receptor for TNF family members APRIL and BLyS. Wu, Y., Bressette, D., Carrell, J.A., Kaufman, T., Feng, P., Taylor, K., Gan, Y., Cho, Y.H., Garcia, A.D., Gollatz, E., Dimke, D., LaFleur, D., Migone, T.S., Nardelli, B., Wei, P., Ruben, S.M., Ullrich, S.J., Olsen, H.S., Kanakaraj, P., Moore, P.A., Baker, K.P. J. Biol. Chem. (2000) [Pubmed]
  41. Local production of B lymphocyte stimulator protein and APRIL in arthritic joints of patients with inflammatory arthritis. Tan, S.M., Xu, D., Roschke, V., Perry, J.W., Arkfeld, D.G., Ehresmann, G.R., Migone, T.S., Hilbert, D.M., Stohl, W. Arthritis Rheum. (2003) [Pubmed]
  42. Abnormal production of the TNF-homologue APRIL increases the proliferation of human malignant glioblastoma cell lines via a specific receptor. Deshayes, F., Laprée, G., Portier, A., Richard, Y., Pencalet, P., Mahieu-Caputo, D., Horellou, P., Tsapis, A. Oncogene (2004) [Pubmed]
  43. Functional expression of a proliferation-related ligand in hepatocellular carcinoma and its implications for neovascularization. Okano, H., Shiraki, K., Yamanaka, Y., Inoue, H., Kawakita, T., Saitou, Y., Yamaguchi, Y., Enokimura, N., Ito, K., Yamamoto, N., Sugimoto, K., Murata, K., Nakano, T. World J. Gastroenterol. (2005) [Pubmed]
  44. Transmission of multidrug-resistant Mycobacterium tuberculosis during a long airplane flight. Kenyon, T.A., Valway, S.E., Ihle, W.W., Onorato, I.M., Castro, K.G. N. Engl. J. Med. (1996) [Pubmed]
 
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