The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

TNFRSF14  -  tumor necrosis factor receptor superfamily...

Homo sapiens

Synonyms: ATAR, CD270, HVEA, HVEM, Herpes virus entry mediator A, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of TNFRSF14


Psychiatry related information on TNFRSF14


High impact information on TNFRSF14

  • The Fly CAMTA Transcription Factor Potentiates Deactivation of Rhodopsin, a G Protein-Coupled Light Receptor [7].
  • The contribution of HVEM to HSV entry into human cells was demonstrable in activated T cells [8].
  • HVEM, the first identified mediator of HSV entry, is a new member of the TNF/NGF receptor family [8].
  • Mutations in the HSV envelope glycoprotein gD significantly reduced HVEM-mediated entry [8].
  • Recently, a two-step process for viral infection involving attachment of virus to a primary receptor (coxsackievirus adenovirus receptor and heparan sulfate proteoglycan) and subsequent mediation of virus entry by a co-receptor (alphaV integrins and HVEM) has been determined for both adenovirus and HSV, respectively [9].

Chemical compound and disease context of TNFRSF14


Biological context of TNFRSF14


Anatomical context of TNFRSF14

  • LIGHT (TNFSF14) and its receptor TR2 (TNFRSF14) are known to have pro-inflammatory activities in foam cells of atherosclerotic plaques [14].
  • According to flow cytometry, recombinant human TR6-Fc binds to human LIGHT expressed on 293 cells or on activated human T cells and competes with the LIGHT receptor TR2 for the binding to LIGHT on these cells [15].
  • We detected HVEM mRNA expression in several human fetal and adult tissues, although the predominant sites of expression were lymphocyte-rich tissues such as adult spleen and peripheral blood leukocytes [12].
  • Our data suggest that TR6 inhibits the interactions of LIGHT with HVEM/TR2 and LTbetaR, thereby suppressing LIGHT- mediated HT29 cell death [13].
  • Proinflammatory effects of LIGHT through HVEM and LTbetaR interactions in cultured human umbilical vein endothelial cells [16].

Associations of TNFRSF14 with chemical compounds


Regulatory relationships of TNFRSF14


Other interactions of TNFRSF14

  • The intracellular domains of human and mouse ATAR share only 25% identity, yet both interact with TRAF5 and TRAF2 [26].
  • HVEM transfection induced also marked activation of Jun N-terminal kinase, and of the Jun-containing transcription factor AP-1, a regulator of cellular stress-response genes [12].
  • Herpesvirus entry mediator (HVEM), a member of the tumor necrosis factor (TNF) receptor family, mediates herpesvirus entry into cells during infection [23].
  • They are (i) HveA (herpesvirus entry mediator A), (ii) members of the nectin family, (iii) 3-O-sulphated heparan sulphate [27].
  • This structure shows that BTLA binds the N-terminal cysteine-rich domain of HVEM and employs a unique binding surface compared with other CD28-like receptors [19].

Analytical, diagnostic and therapeutic context of TNFRSF14


  1. Tumor necrosis factor receptor and ligand superfamily family members TNFRSF14 and LIGHT: new players in human atherogenesis. Bobik, A., Kalinina, N. Arterioscler. Thromb. Vasc. Biol. (2001) [Pubmed]
  2. Evolutionarily divergent herpesviruses modulate T cell activation by targeting the herpesvirus entry mediator cosignaling pathway. Cheung, T.C., Humphreys, I.R., Potter, K.G., Norris, P.S., Shumway, H.M., Tran, B.R., Patterson, G., Jean-Jacques, R., Yoon, M., Spear, P.G., Murphy, K.M., Lurain, N.S., Benedict, C.A., Ware, C.F. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  3. Comparative usage of herpesvirus entry mediator A and nectin-1 by laboratory strains and clinical isolates of herpes simplex virus. Krummenacher, C., Baribaud, F., Ponce de Leon, M., Baribaud, I., Whitbeck, J.C., Xu, R., Cohen, G.H., Eisenberg, R.J. Virology (2004) [Pubmed]
  4. LIGHT, a new member of the TNF superfamily, and lymphotoxin alpha are ligands for herpesvirus entry mediator. Mauri, D.N., Ebner, R., Montgomery, R.I., Kochel, K.D., Cheung, T.C., Yu, G.L., Ruben, S., Murphy, M., Eisenberg, R.J., Cohen, G.H., Spear, P.G., Ware, C.F. Immunity (1998) [Pubmed]
  5. Dual transforming activities of the FUS (TLS)-ERG leukemia fusion protein conferred by two N-terminal domains of FUS (TLS). Ichikawa, H., Shimizu, K., Katsu, R., Ohki, M. Mol. Cell. Biol. (1999) [Pubmed]
  6. Tomoregulin-2 is found extensively in plaques in Alzheimer's disease brain. Siegel, D.A., Davies, P., Dobrenis, K., Huang, M. J. Neurochem. (2006) [Pubmed]
  7. The Fly CAMTA Transcription Factor Potentiates Deactivation of Rhodopsin, a G Protein-Coupled Light Receptor. Han, J., Gong, P., Reddig, K., Mitra, M., Guo, P., Li, H.S. Cell (2006) [Pubmed]
  8. Herpes simplex virus-1 entry into cells mediated by a novel member of the TNF/NGF receptor family. Montgomery, R.I., Warner, M.S., Lum, B.J., Spear, P.G. Cell (1996) [Pubmed]
  9. AlphaVbeta5 integrin: a co-receptor for adeno-associated virus type 2 infection. Summerford, C., Bartlett, J.S., Samulski, R.J. Nat. Med. (1999) [Pubmed]
  10. Mutations in the N termini of herpes simplex virus type 1 and 2 gDs alter functional interactions with the entry/fusion receptors HVEM, nectin-2, and 3-O-sulfated heparan sulfate but not with nectin-1. Yoon, M., Zago, A., Shukla, D., Spear, P.G. J. Virol. (2003) [Pubmed]
  11. Monoclonal antibodies to distinct sites on herpes simplex virus (HSV) glycoprotein D block HSV binding to HVEM. Nicola, A.V., Ponce de Leon, M., Xu, R., Hou, W., Whitbeck, J.C., Krummenacher, C., Montgomery, R.I., Spear, P.G., Eisenberg, R.J., Cohen, G.H. J. Virol. (1998) [Pubmed]
  12. Herpesvirus entry mediator, a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and activates the transcription factors NF-kappaB and AP-1. Marsters, S.A., Ayres, T.M., Skubatch, M., Gray, C.L., Rothe, M., Ashkenazi, A. J. Biol. Chem. (1997) [Pubmed]
  13. A newly identified member of tumor necrosis factor receptor superfamily (TR6) suppresses LIGHT-mediated apoptosis. Yu, K.Y., Kwon, B., Ni, J., Zhai, Y., Ebner, R., Kwon, B.S. J. Biol. Chem. (1999) [Pubmed]
  14. LIGHT is involved in the pathogenesis of rheumatoid arthritis by inducing the expression of pro-inflammatory cytokines and MMP-9 in macrophages. Kim, W.J., Kang, Y.J., Koh, E.M., Ahn, K.S., Cha, H.S., Lee, W.H. Immunology (2005) [Pubmed]
  15. Modulation of T-cell responses to alloantigens by TR6/DcR3. Zhang, J., Salcedo, T.W., Wan, X., Ullrich, S., Hu, B., Gregorio, T., Feng, P., Qi, S., Chen, H., Cho, Y.H., Li, Y., Moore, P.A., Wu, J. J. Clin. Invest. (2001) [Pubmed]
  16. Proinflammatory effects of LIGHT through HVEM and LTbetaR interactions in cultured human umbilical vein endothelial cells. Chang, Y.H., Hsieh, S.L., Chao, Y., Chou, Y.C., Lin, W.W. J. Biomed. Sci. (2005) [Pubmed]
  17. Specific association of glycoprotein B with lipid rafts during herpes simplex virus entry. Bender, F.C., Whitbeck, J.C., Ponce de Leon, M., Lou, H., Eisenberg, R.J., Cohen, G.H. J. Virol. (2003) [Pubmed]
  18. Mutations in herpes simplex virus glycoprotein D that prevent cell entry via nectins and alter cell tropism. Manoj, S., Jogger, C.R., Myscofski, D., Yoon, M., Spear, P.G. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  19. Attenuating lymphocyte activity: the crystal structure of the BTLA-HVEM complex. Compaan, D.M., Gonzalez, L.C., Tom, I., Loyet, K.M., Eaton, D., Hymowitz, S.G. J. Biol. Chem. (2005) [Pubmed]
  20. Fate Determination of the Flavin Photoreceptions in the Cyanobacterial Blue Light Receptor TePixD (Tll0078). Okajima, K., Fukushima, Y., Suzuki, H., Kita, A., Ochiai, Y., Katayama, M., Shibata, Y., Miki, K., Noguchi, T., Itoh, S., Ikeuchi, M. J. Mol. Biol. (2006) [Pubmed]
  21. High voltage immunoelectron microscopy of complement receptor type 3-mediated capping and internalization of group A streptococcal cell walls by human neutrophils. Pryzwansky, K.B. Microsc. Res. Tech. (1994) [Pubmed]
  22. HVEM signaling in monocytes is mediated by intracellular calcium mobilization. Heo, S.K., Yoon, M.A., Lee, S.C., Ju, S.A., Choi, J.H., Suh, P.G., Kwon, B.S., Kim, B.S. J. Immunol. (2007) [Pubmed]
  23. Herpesvirus entry mediator ligand (HVEM-L), a novel ligand for HVEM/TR2, stimulates proliferation of T cells and inhibits HT29 cell growth. Harrop, J.A., McDonnell, P.C., Brigham-Burke, M., Lyn, S.D., Minton, J., Tan, K.B., Dede, K., Spampanato, J., Silverman, C., Hensley, P., DiPrinzio, R., Emery, J.G., Deen, K., Eichman, C., Chabot-Fletcher, M., Truneh, A., Young, P.R. J. Biol. Chem. (1998) [Pubmed]
  24. Tumor necrosis factor receptor superfamily 14 is involved in atherogenesis by inducing proinflammatory cytokines and matrix metalloproteinases. Lee, W.H., Kim, S.H., Lee, Y., Lee, B.B., Kwon, B., Song, H., Kwon, B.S., Park, J.E. Arterioscler. Thromb. Vasc. Biol. (2001) [Pubmed]
  25. Induction of caspase 8 by interferon gamma renders some neuroblastoma (NB) cells sensitive to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) but reveals that a lack of membrane TR1/TR2 also contributes to TRAIL resistance in NB. Yang, X., Merchant, M.S., Romero, M.E., Tsokos, M., Wexler, L.H., Kontny, U., Mackall, C.L., Thiele, C.J. Cancer Res. (2003) [Pubmed]
  26. ATAR, a novel tumor necrosis factor receptor family member, signals through TRAF2 and TRAF5. Hsu, H., Solovyev, I., Colombero, A., Elliott, R., Kelley, M., Boyle, W.J. J. Biol. Chem. (1997) [Pubmed]
  27. The novel receptors that mediate the entry of herpes simplex viruses and animal alphaherpesviruses into cells. Campadelli-Fiume, G., Cocchi, F., Menotti, L., Lopez, M. Rev. Med. Virol. (2000) [Pubmed]
  28. Intrahepatic gene expression in human alcoholic hepatitis. Seth, D., Gorrell, M.D., Cordoba, S., McCaughan, G.W., Haber, P.S. J. Hepatol. (2006) [Pubmed]
  29. A newly identified member of the tumor necrosis factor receptor superfamily with a wide tissue distribution and involvement in lymphocyte activation. Kwon, B.S., Tan, K.B., Ni, J., Oh, K.O., Lee, Z.H., Kim, K.K., Kim, Y.J., Wang, S., Gentz, R., Yu, G.L., Harrop, J., Lyn, S.D., Silverman, C., Porter, T.G., Truneh, A., Young, P.R. J. Biol. Chem. (1997) [Pubmed]
  30. Kinetic analysis of glycoprotein C of herpes simplex virus types 1 and 2 binding to heparin, heparan sulfate, and complement component C3b. Rux, A.H., Lou, H., Lambris, J.D., Friedman, H.M., Eisenberg, R.J., Cohen, G.H. Virology (2002) [Pubmed]
  31. Overexpression of CIN85 suppresses the growth of herpes simplex virus in HeLa cells. Narita, T., Ando, A., Mikami, Y., Taniyama, T. Exp. Cell Res. (2005) [Pubmed]
WikiGenes - Universities