Gene Review:
FADD - Fas (TNFRSF6)-associated via death domain
Homo sapiens
Synonyms:
FAS-associated death domain protein, FAS-associating death domain-containing protein, GIG3, Growth-inhibiting gene 3 protein, MORT1, ...
- Tumor necrosis factor alpha in the pathogenesis of human and murine fulminant hepatic failure. Streetz, K., Leifeld, L., Grundmann, D., Ramakers, J., Eckert, K., Spengler, U., Brenner, D., Manns, M., Trautwein, C. Gastroenterology (2000)
- Fas-associated death domain protein interacts with methyl-CpG binding domain protein 4: a potential link between genome surveillance and apoptosis. Screaton, R.A., Kiessling, S., Sansom, O.J., Millar, C.B., Maddison, K., Bird, A., Clarke, A.R., Frisch, S.M. Proc. Natl. Acad. Sci. U.S.A. (2003)
- Molecular and functional interaction of the ATP-binding cassette transporter A1 with Fas-associated death domain protein. Buechler, C., Bared, S.M., Aslanidis, C., Ritter, M., Drobnik, W., Schmitz, G. J. Biol. Chem. (2002)
- Taxol induces caspase-10-dependent apoptosis. Park, S.J., Wu, C.H., Gordon, J.D., Zhong, X., Emami, A., Safa, A.R. J. Biol. Chem. (2004)
- FADD gene therapy for malignant gliomas in vitro and in vivo. Kondo, S., Ishizaka, Y., Okada, T., Kondo, Y., Hitomi, M., Tanaka, Y., Haqqi, T., Barnett, G.H., Barna, B.P. Hum. Gene Ther. (1998)
- Amplicon mapping and expression profiling identify the Fas-associated death domain gene as a new driver in the 11q13.3 amplicon in laryngeal/pharyngeal cancer. Gibcus, J.H., Menkema, L., Mastik, M.F., Hermsen, M.A., de Bock, G.H., van Velthuysen, M.L., Takes, R.P., Kok, K., Alvarez Marcos, C.A., van der Laan, B.F., van den Brekel, M.W., Langendijk, J.A., Kluin, P.M., van der Wal, J.E., Schuuring, E. Clin. Cancer Res. (2007)
- Signaling for survival and apoptosis in the immune system. Mak, T.W., Yeh, W.C. Arthritis Res. (2002)
- Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes. Micheau, O., Tschopp, J. Cell (2003)
- Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death. Boldin, M.P., Goncharov, T.M., Goltsev, Y.V., Wallach, D. Cell (1996)
- Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell death. Liu, Z.G., Hsu, H., Goeddel, D.V., Karin, M. Cell (1996)
- FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death--inducing signaling complex. Muzio, M., Chinnaiyan, A.M., Kischkel, F.C., O'Rourke, K., Shevchenko, A., Ni, J., Scaffidi, C., Bretz, J.D., Zhang, M., Gentz, R., Mann, M., Krammer, P.H., Peter, M.E., Dixit, V.M. Cell (1996)
- FADD phosphorylation is critical for cell cycle regulation in breast cancer cells. Matsuyoshi, S., Shimada, K., Nakamura, M., Ishida, E., Konishi, N. Br. J. Cancer (2006)
- Phosphorylation status of Fas-associated death domain-containing protein (FADD) is associated with prostate cancer progression. Shimada, K., Matsuyoshi, S., Nakamura, M., Ishida, E., Konishi, N. J. Pathol. (2005)
- STAT-1-independent upregulation of FADD and procaspase-3 and -8 in cancer cells treated with cytotoxic drugs. Micheau, O., Hammann, A., Solary, E., Dimanche-Boitrel, M.T. Biochem. Biophys. Res. Commun. (1999)
- The adaptor protein TRADD activates distinct mechanisms of apoptosis from the nucleus and the cytoplasm. Bender, L.M., Morgan, M.J., Thomas, L.R., Liu, Z.G., Thorburn, A. Cell Death Differ. (2005)
- Phosphorylation of FADD/ MORT1 at serine 194 and association with a 70-kDa cell cycle-regulated protein kinase. Scaffidi, C., Volkland, J., Blomberg, I., Hoffmann, I., Krammer, P.H., Peter, M.E. J. Immunol. (2000)
- Fas ligand-independent, FADD-mediated activation of the Fas death pathway by anticancer drugs. Micheau, O., Solary, E., Hammann, A., Dimanche-Boitrel, M.T. J. Biol. Chem. (1999)
- A dominant interfering mutant of FADD/MORT1 enhances deletion of autoreactive thymocytes and inhibits proliferation of mature T lymphocytes. Newton, K., Harris, A.W., Bath, M.L., Smith, K.G., Strasser, A. EMBO J. (1998)
- Defective CD95/APO-1/Fas signal complex formation in the human autoimmune lymphoproliferative syndrome, type Ia. Martin, D.A., Zheng, L., Siegel, R.M., Huang, B., Fisher, G.H., Wang, J., Jackson, C.E., Puck, J.M., Dale, J., Straus, S.E., Peter, M.E., Krammer, P.H., Fesik, S., Lenardo, M.J. Proc. Natl. Acad. Sci. U.S.A. (1999)
- Inhibition of death receptor-mediated gene induction by a cycloheximide-sensitive factor occurs at the level of or upstream of Fas-associated death domain protein (FADD). Wajant, H., Haas, E., Schwenzer, R., Muhlenbeck, F., Kreuz, S., Schubert, G., Grell, M., Smith, C., Scheurich, P. J. Biol. Chem. (2000)
- Activation of CD95 (APO-1/Fas) signaling by ceramide mediates cancer therapy-induced apoptosis. Herr, I., Wilhelm, D., Böhler, T., Angel, P., Debatin, K.M. EMBO J. (1997)
- Herpes simplex virus thymidine kinase/ganciclovir-induced apoptosis involves ligand-independent death receptor aggregation and activation of caspases. Beltinger, C., Fulda, S., Kammertoens, T., Meyer, E., Uckert, W., Debatin, K.M. Proc. Natl. Acad. Sci. U.S.A. (1999)
- Fas-associated factor 1, FAF1, is a member of Fas death-inducing signaling complex. Ryu, S.W., Lee, S.J., Park, M.Y., Jun, J.I., Jung, Y.K., Kim, E. J. Biol. Chem. (2003)
- Fas-associated death domain protein interleukin-1beta-converting enzyme 2 (FLICE2), an ICE/Ced-3 homologue, is proximally involved in CD95- and p55-mediated death signaling. Vincenz, C., Dixit, V.M. J. Biol. Chem. (1997)
- Regulation of Fas-associated death domain interactions by the death effector domain identified by a modified reverse two-hybrid screen. Thomas, L.R., Stillman, D.J., Thorburn, A. J. Biol. Chem. (2002)
- Fas-associated protein with death domain (FADD)-independent recruitment of c-FLIPL to death receptor 5. Jin, T.G., Kurakin, A., Benhaga, N., Abe, K., Mohseni, M., Sandra, F., Song, K., Kay, B.K., Khosravi-Far, R. J. Biol. Chem. (2004)
- Selective induction of apoptosis through the FADD/caspase-8 pathway by a p53 c-terminal peptide in human pre-malignant and malignant cells. Li, Y., Mao, Y., Rosal, R.V., Dinnen, R.D., Williams, A.C., Brandt-Rauf, P.W., Fine, R.L. Int. J. Cancer (2005)
- JNK regulates HIPK3 expression and promotes resistance to Fas-mediated apoptosis in DU 145 prostate carcinoma cells. Curtin, J.F., Cotter, T.G. J. Biol. Chem. (2004)
- FADD/MORT1 is a common mediator of CD95 (Fas/APO-1) and tumor necrosis factor receptor-induced apoptosis. Chinnaiyan, A.M., Tepper, C.G., Seldin, M.F., O'Rourke, K., Kischkel, F.C., Hellbardt, S., Krammer, P.H., Peter, M.E., Dixit, V.M. J. Biol. Chem. (1996)
- c-E10 is a caspase-recruiting domain-containing protein that interacts with components of death receptors signaling pathway and activates nuclear factor-kappaB. Costanzo, A., Guiet, C., Vito, P. J. Biol. Chem. (1999)
- Fas-associated death domain protein and caspase-8 are not recruited to the tumor necrosis factor receptor 1 signaling complex during tumor necrosis factor-induced apoptosis. Harper, N., Hughes, M., MacFarlane, M., Cohen, G.M. J. Biol. Chem. (2003)
- FLAME-1, a novel FADD-like anti-apoptotic molecule that regulates Fas/TNFR1-induced apoptosis. Srinivasula, S.M., Ahmad, M., Ottilie, S., Bullrich, F., Banks, S., Wang, Y., Fernandes-Alnemri, T., Croce, C.M., Litwack, G., Tomaselli, K.J., Armstrong, R.C., Alnemri, E.S. J. Biol. Chem. (1997)
- TRAIL receptors 1 (DR4) and 2 (DR5) signal FADD-dependent apoptosis and activate NF-kappaB. Schneider, P., Thome, M., Burns, K., Bodmer, J.L., Hofmann, K., Kataoka, T., Holler, N., Tschopp, J. Immunity (1997)
- A GTP-binding adapter protein couples TRAIL receptors to apoptosis-inducing proteins. Miyazaki, T., Reed, J.C. Nat. Immunol. (2001)
- Molecular ordering of the Fas-apoptotic pathway: the Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE-like cysteine proteases. Srinivasula, S.M., Ahmad, M., Fernandes-Alnemri, T., Litwack, G., Alnemri, E.S. Proc. Natl. Acad. Sci. U.S.A. (1996)
- Interferon gamma induces upregulation and activation of caspases 1, 3, and 8 to produce apoptosis in human erythroid progenitor cells. Dai, C., Krantz, S.B. Blood (1999)
- Cell death attenuation by 'Usurpin', a mammalian DED-caspase homologue that precludes caspase-8 recruitment and activation by the CD-95 (Fas, APO-1) receptor complex. Rasper, D.M., Vaillancourt, J.P., Hadano, S., Houtzager, V.M., Seiden, I., Keen, S.L., Tawa, P., Xanthoudakis, S., Nasir, J., Martindale, D., Koop, B.F., Peterson, E.P., Thornberry, N.A., Huang, J., MacPherson, D.P., Black, S.C., Hornung, F., Lenardo, M.J., Hayden, M.R., Roy, S., Nicholson, D.W. Cell Death Differ. (1998)
- NMR structure and mutagenesis of the Fas (APO-1/CD95) death domain. Huang, B., Eberstadt, M., Olejniczak, E.T., Meadows, R.P., Fesik, S.W. Nature (1996)
- Ultraviolet light induces apoptosis via direct activation of CD95 (Fas/APO-1) independently of its ligand CD95L. Aragane, Y., Kulms, D., Metze, D., Wilkes, G., Pöppelmann, B., Luger, T.A., Schwarz, T. J. Cell Biol. (1998)
- Involvement of Fas (APO-1/CD-95) during photodynamic-therapy-mediated apoptosis in human epidermoid carcinoma A431 cells. Ahmad, N., Gupta, S., Feyes, D.K., Mukhtar, H. J. Invest. Dermatol. (2000)